Acquisition of Biacore T-100 at URI

描述（由申请人提供）：我们希望获得Biacore T-100，一种采用表面等离子体共振（SPR）技术的基于芯片的生物传感仪器。该工具将为罗得岛大学（URI）的生物医学研究人员提供研究动态大分子相互作用的最先进能力。URI的生物医学和分子科学社区在过去几年中显着增长，我们现在拥有SPR用户的临界质量：6个R 01受资助者作为主要用户和15个次要用户，其中许多人获得了NIH和其他机构的大量资金支持。这些研究人员隶属于四个不同的学院：药学，艺术与科学，环境与生命科学和工程。拟议的研究项目是多样化和跨学科的性质，涉及纳米技术用于癌症成像和治疗，激酶-底物相互作用，核受体相互作用，以及复制叉构象对突变和修复的影响。因此，我们准备立即使用这一新工具。

DESCRIPTION (provided by applicant): We wish to acquire a Biacore T-100, a chip-based biosensing instrument employing surface plasmon resonance (SPR) technology. This tool will provide biomedical investigators at the University of Rhode Island (URI) with state-of the-art capability for studying dynamic macromolecular interactions. The biomedical and molecular science community at URI has grown significantly in the past several years and we now have a critical mass of SPR users: six R01 grantees as major users and 15 minor users, many of whom have substantial funding support from NIH and other agencies. These investigators are affiliated with four different colleges: Pharmacy, Arts & Sciences, Environmental & Life Sciences, and Engineering. The proposed research projects are diverse and interdisciplinary in nature, involving nanotechnology for cancer imaging and therapy, kinase-substrate interactions, nuclear receptor interactions, and the effect of replication fork conformation on mutation & repair. Consequently, we are poised to make immediate use of the new instrument.