Core B - Sheep Core

绵羊核心的目标是提供一种机制，使普通人员的服务 由本计划项目赠款的所有项目共享，以实现经济高效的养殖和动物 格外高标准的维护计划。这个核心的基本原理很简单。一个 高素质的人员可以更有效地满足多个研究项目的需求 从经济上讲，如果每个项目都要单独满足其需求，这是不可能的。这尤其重要，因为 这个核心的主要功能将是产生通过暴露于 已知怀孕阶段的性腺类固醇。这需要丰富的经验和专业知识 在这个实验物种中管理生育、繁殖和早期产后护理。《公约》的具体目标 绵羊核心如下。具体目标1.实施育种计划，以产生以下绵羊 在特定胎龄使用性腺类固醇进行产前治疗，并使用车辆处理的对照 三个研究项目组成了这项计划的项目资助。具体目标2.有效协调 三个相互关联的研究项目对绵羊的经济利用。具体目标3.提供一个 统一、高标准的动物养护和兽医护理。具体目标4.提供一个 绵羊生殖研究的技术知识库，并培训适当处理绵羊生殖的人员 动物。具体目标5.确定所需实验动物的代谢状态 满足所有3个项目的需求。通过实现这些目标，羊芯将极大地增强 计划项目赠款中所有项目的生产率。

The objective of the Sheep Core is to provide a mechanism whereby the services of common personnel are shared by all projects of this Program Project Grant, enabling cost-effective breeding and animal maintenance programs of exceptionally high standards. The underlying rationale for this Core is simple. A staff of well-qualified individuals can meet the needs of multiple research projects more effectively and economically than if each project were to meet its needs separately. This is especially important given that a major function of this core will be to generate sheep that have been programmed prenatally by exposure to gonadal steroids at known stages of pregnancy. This requires extensive experience and expertise of managing fertility, breeding, and early postnatal care in this experimental species. The Specific Aims of the Sheep Core are as follows. Specific Aim 1. To operate a breeding program to generate sheep those are prenatally treated with gonadal steroids at specific fetal ages and vehicle-treated controls for use by the three research projects that make up this Program Project Grant. Specific Aim 2. To coordinate effective and economical usage of sheep by three interrelated research projects. Specific Aim 3. To provide a uniform and high standard of animal maintenance and veterinary care. Specific Aim 4. To provide a technical knowledge base for reproductive research in sheep and train personnel in proper handling of animals. Specific Aim 5. To determine the metabolic status of the experimental animals required for meeting the needs of all 3 projects. By achieving these aims, the Sheep Core will greatly enhance the productivity of all projects in the Program Project Grant.