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Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome

生命全程暴露

基本信息

批准号：
8512938
负责人：
VASANTHA PADMANABHAN
金额：
$ 67.72万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8512938
关键词：
Address Adult Advisory Committees Affect Age Amino Acids Animals Area Award Bioinformatics Biological Markers Biometry Birth Cadmium Carnitine Child Child Development Child health care Childhood Chromatin Remodeling Factor Chromatin Structure Chronic Disease Clinical Collaborations Communication Communities Community Healthcare Community Outreach Complex DNA Methylation Data Data Analyses Databases Development Development Plans Developmental Biology Diet Dietary intake Discipline Disease Disease susceptibility Elements Endocrine Disruptors Ensure Environmental Exposure Environmental Health Environmental Risk Factor Epidemiology Epigenetic Process Exposure to Faculty Fetal Development Fostering Funding Gene Expression Profile Gene Expression Regulation Genes Genetic Transcription Goals Government Growth Health Health Professional Homeostasis Hormonal Change Human Infant Influentials Informatics Interdisciplinary Study Intervention Knowledge Lead Learning Letters Life Life Cycle Stages Literature Metabolic Metabolic syndrome Metabolism Methylation Mexico Michigan Modeling Mothers National Institute of Environmental Health Sciences Nonesterified Fatty Acids Nutritional Obesity Outcome Output Outreach Research Oxidative Stress Perinatal Perinatal Exposure Phenotype Play Policies Policy Maker Population Study Positioning Attribute Predisposition Pregnancy in Adolescence Prevention Research Principal Investigator Procedures Process Protocols documentation Public Health Quality Control Relative (related person)Reporting Research Research Design Research Infrastructure Research Personnel Research Project Grants Resources Risk Risk Assessment Role Sampling Scientist Secure Services Sexual Maturation Specialist Staging Stress Thinking Tissues Toxic Environmental Substances Training Training Activity Translational Research Translations Tyrosine United States Environmental Protection Agency United States National Institutes of Health Universities Vision Weight base behavior influence bisphenol A body system career career development cohort cost data management data mining design developmental plasticity discount disorder prevention early life exposure epigenome epigenomics fetal follow-up in utero insight interdisciplinary approach meetings member metabolomics next generation novel nutrition organizational structure oxidation peripubertal period phthalates postnatal programs ranpirnase reproductive hormone response skills success tool transcriptomics

项目摘要

DESCRIPTION (provided by applicant) The overall goal of the Administrative Core (AC) is to provide oversight, coordination and integration of Center activities. The specific aims are to: 1) Coordinate and integrate the scientific aims of the Projects and Cores, track and evaluate progress and outputs, and ensure successful completion of all Center aims; 2) Manage resources to assure the needs and priorities of every Project and Cores are met; 3) Act as coordinating center by convening meetings of Project, Core, and subcontract investigators, organize External Advisory Committee, ensure timely translation of research findings, prepare Center-wide reports, and interface with NIEHS and EPA project officers; 4) Evaluate the progress and success of the career, development plan, with specific focus on the career development of Faculty Development Investigator; 5) Ensure quality control of all stages of research namely study design, establishment of standard operating procedures and study protocols, secure sample and data transfer and management, data analysis, and accurate interpretation and translation of research findings to academic, government, healthcare and community stakeholders. The AC will operate under the direction of the Core co-Leaders, Consultant, and Pediatric Health Specialist in collaboration with Leaders of each Project and Core. The AC will ensure coordination of Center activities, manage resources across Projects and Cores, identify the most efficient use of infrastructure and communication and resolve needs as they arise, in order to increase the efficiency and productive output of the Center. AC Leaders will interact with the External Advisory Board to ensure the merit and value of all UM-CEHC elements to accomplish the overall Center aims. The Center Manager will prioritize coordination with the Community Outreach and Translation Core to optimize outreach and research translation to community stakeholders. Finally, the AC will oversee career development and training of New Investigators, particularly the UM-CEHC Co-investigator designated as the Faculty Development Investigator. Career development and training activities will draw upon extensive institutional resources and will be fully integrated with the Center's Research Projects and Cores.

描述（由申请人提供）行政核心 (AC) 的总体目标是对中心活动进行监督、协调和整合。具体目标是： 1）协调和整合项目和核心的科学目标，跟踪和评估进展和产出，并确保成功完成所有中心目标； 2）管理资源以确保满足每个项目和核心的需求和优先级； 3) 作为协调中心，召开项目、核心和分包研究人员会议，组织外部咨询委员会，确保研究成果的及时翻译，准备中心范围的报告，并与 NIEHS 和 EPA 项目官员进行沟通； 4）评估职业发展计划的进展和成功，特别关注教师发展研究员的职业发展； 5) 确保研究各个阶段的质量控制，即研究设计、建立标准操作程序和研究方案、安全样本和数据传输和管理、数据分析以及向学术、政府、医疗保健和社区利益相关者准确解释和翻译研究结果。 AC 将在核心联合领导者、顾问和儿科健康专家的指导下与每个项目和核心的领导者合作运作。审计委员会将确保中心活动的协调，管理跨项目和核心的资源，确定基础设施和通信的最有效利用，并解决出现的需求，以提高中心的效率和生产力。 AC 领导人将与外部顾问委员会互动，以确保所有 UM-CEHC 要素的优点和价值，以实现中心的总体目标。中心经理将优先考虑与社区外展和翻译核心的协调，以优化对社区利益相关者的外展和研究翻译。最后，AC 将监督新研究员的职业发展和培训，特别是被指定为教师发展研究员的 UM-CEHC 联合研究员。职业发展和培训活动将利用广泛的机构资源，并将与中心的研究项目和核心充分结合。