SPORE in Gastrointestinal Cancer

胃肠癌中的孢子

• 批准号: 7900984
• 负责人: Michael A. Hollingsworth
• 金额: $ 106.67万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-05 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7900984
• 关键词: SPORE; Gastrointestinal; Cancer

This application for a Specialized Program of Research Excellence in Gastrointestinal (Pancreatic Cancer) will focus on translational studies that address basic and clinical issues of importance to improving the outcome of patients with pancreatic cancer. Specifically, the research projects in this program seek to: 1) develop and test novel diagnostic reagents and assays that will improve our ability to detect pancreatic cancer in its early stages; 2) develop and test novel therapeutic strategies including immunotherapy, chemotherapy, and chemoradiation therapy for patients with early and advanced pancreatic cancer; 3) undertake basic research studies in conjunction with clinical trials that will provide insight at the molecular level into the reasons for success and failure of the different strategies. The proposed SPORE program is focused on 4 projects with the high potential translational impact, and there are 2 highly interactive cores that will continue to acquire, store, and make available a unique set of tissue samples, data (clinical, molecular genetic, biological, pathological), reagents and resources: Project 1: Immunotherapy of Pancreatic Adenocarcinoma Project 2: Inhibitors of N-cadherin in the treatment of pancreatic cancer. Project 3: Biological marker(s) in the diagnosis of pancreatic cancer Project 4: Inhibitors of Telomerase in treatment of pancreatic adenocarcinoma Core 1: Administration Core 2: Pancreas Tumor SPORE Tissue Bank Core 3: Biostatistics

这项胃肠道（胰腺癌）卓越研究专门计划的申请将重点关注转化研究，这些研究解决对改善胰腺癌患者的预后具有重要意义的基本和临床问题。具体来说，该计划中的研究项目旨在：1）开发和测试新型诊断试剂和检测方法，以提高我们在早期阶段检测胰腺癌的能力； 2）针对早期和晚期胰腺癌患者开发和测试新的治疗策略，包括免疫疗法、化疗和放化疗； 3）结合临床试验开展基础研究，从分子水平深入了解不同策略成功和失败的原因。拟议的 SPORE 计划重点关注 4 个具有高潜在转化影响的项目，有 2 个高度互动的核心，将继续获取、存储和提供一组独特的组织样本、数据（临床、分子遗传、生物、病理）、试剂和资源： 项目一：胰腺癌的免疫治疗 项目2：N-钙粘蛋白抑制剂治疗胰腺癌。 项目3：诊断胰腺癌的生物标志物 项目4：端粒酶抑制剂治疗胰腺癌 核心 1：管理 核心2：胰腺肿瘤孢子组织库 核心3：生物统计学