SPORE in Gastrointestinal Cancer

本申请为胃肠道（胰腺癌）卓越研究专业项目，将专注于解决对改善胰腺癌患者预后具有重要意义的基础和临床问题的转化研究。具体来说，该计划的研究项目旨在：1)开发和测试新的诊断试剂和分析方法，以提高我们在早期阶段检测胰腺癌的能力；2)为早期和晚期胰腺癌患者开发和测试新的治疗策略，包括免疫治疗、化疗和放化疗；3)结合临床试验开展基础研究，在分子水平上洞察不同策略的成败原因。拟建的SPORE项目集中在4个具有高潜在转化影响的项目上，有2个高度互动的核心将继续获取、存储和提供一套独特的组织样本、数据（临床、分子遗传学、生物学、病理学）、试剂和资源：

This application for a Specialized Program of Research Excellence in Gastrointestinal (Pancreatic Cancer) will focus on translational studies that address basic and clinical issues of importance to improving the outcome of patients with pancreatic cancer. Specifically, the research projects in this program seek to: 1) develop and test novel diagnostic reagents and assays that will improve our ability to detect pancreatic cancer in its early stages; 2) develop and test novel therapeutic strategies including immunotherapy, chemotherapy, and chemoradiation therapy for patients with early and advanced pancreatic cancer; 3) undertake basic research studies in conjunction with clinical trials that will provide insight at the molecular level into the reasons for success and failure of the different strategies. The proposed SPORE program is focused on 4 projects with the high potential translational impact, and there are 2 highly interactive cores that will continue to acquire, store, and make available a unique set of tissue samples, data (clinical, molecular genetic, biological, pathological), reagents and resources: Project 1: Immunotherapy of Pancreatic Adenocarcinoma Project 2: Inhibitors of N-cadherin in the treatment of pancreatic cancer. Project 3: Biological marker(s) in the diagnosis of pancreatic cancer Project 4: Inhibitors of Telomerase in treatment of pancreatic adenocarcinoma Core 1: Administration Core 2: Pancreas Tumor SPORE Tissue Bank Core 3: Biostatistics