Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal Cancer

项目总结/摘要：总体 这份申请是范德比尔特-英格拉姆癌症中心GI SPORE的新提交，将重点关注 结肠直肠癌是美国癌症相关死亡的第二大原因。我们的潜力 成功是高的基础上1）生产力在我们以前的GI孢子的最后一个周期，2）非常强大 机构支持，3）通过职业提升招募有才华的研究人员到GI癌症领域 和发展研究资金，4）获得无与伦比的药物发现和小动物资源 影像学，5）年轻和经验丰富的临床研究人员和基础科学家在一个高度合作的混合体 学院环境，6）一个致力于病人倡导者的团体，现在组织成一个病人倡导理事会 以及7）多个跨SPORE、制药、国家和国际的横向和纵向合作。 我们提出了三个项目和三个支撑核心。 项目核心 1：询问CRC中不同的肿瘤起始细胞1：组织病理学和细胞分析 第2章：靶向谷氨酰胺代谢以增强EGFR 2：小鼠和人类分子成像 野生型RAS CRC中的阻塞 第3章：在CRC中靶向MYC 3：生物统计学和生物信息学

PROJECT SUMMARY/ABSTRACT: Overall This application is a new submission of the Vanderbilt-Ingram Cancer Center GI SPORE, which will focus on colorectal cancer, the second leading cause of cancer-related deaths in the United States. Our potential for success is high based on 1) productivity during the last cycle of our prior GI SPORE, 2) exceedingly strong institutional support, 3) recruitment of talented investigators to the field of GI cancer through career enhancement and developmental research funding, 4) access to unparalleled resources for drug discovery and small animal imaging, 5) a blend of young and seasoned clinical investigators and basic scientists working together in a highly collegial environment, 6) a committed group of patient advocates now organized into a patient advocacy council and 7) multiple inter-SPORE, pharmaceutical, national and international horizontal and vertical collaborations. We propose three projects and three supporting cores. Projects Cores 1: Interrogating Distinct Tumor-Initiating Cells in CRC 1: Tissue Pathology and Cellular Analysis 2: Targeting Glutamine Metabolism to Enhance EGFR 2: Mouse and Human Molecular Imaging Blockade in Wild-Type RAS CRC 3: Targeting MYC in CRC 3: Biostatistics and Bioinformatics