NEAR INFRARED SPECTROSCOPY FOR HEMODYNAMIC MONITORING IN NEONATES UNDERGOING

用于新生儿血流动力学监测的近红外光谱

• 批准号: 8356758
• 负责人: OLUYINKA OLUROTIMI OLUTOYE
• 金额: $ 0.01万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356758
• 关键词: Acidosis; Age-Years; Arteries; Bilateral; Birth; Blood; Blood capillaries; Blood gas; Brain; Brain region; Cannulas; Cerebral hemisphere; Cerebrum; Clinical Research; Control Groups; Data; Defect; Diaphragmatic Hernia; Extracorporeal Membrane Oxygenation; Funding; Grant; Incidence; Kidney; Kidney Failure; Life; Ligation; Magnetic Resonance Imaging; Mechanical ventilation; Monitor; National Center for Research Resources; Near-Infrared Spectroscopy; Neurologic; Newborn Infant; Observational Study; Operative Surgical Procedures; Outcome; Oxygen; Patients; Perfusion; Principal Investigator; Research; Research Infrastructure; Resources; Risk; Source; Techniques; Technology; Time; Tissues; United States National Institutes of Health; Venous; Weaning; Weight; capillary; congenital heart disorder; cost; hemodynamics; indexing; neonatal pulmonary hypertension; neonate; repaired; venule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Extracorporeal membrane oxygenation (ECMO) is an accepted therapy for newborns with life-threatening conditions such as diaphragmatic hernia, pulmonary hypertension of the newborn and severe congenital heart disease. These patients are at risk of compromised cerebral perfusion and/or of developing renal failure during ECMO. The efficacy of tissue perfusion in these patients is estimated by a variety of indirect means tissue lactate content, acidosis, blood gas parameters, etc. The primary purpose of this observational study is to assess bilateral cerebral oxygenation when one cerebral hemisphere is potentially compromised, i.e. unilateral carotid ligation or large venous cannula. Furthermore, we hope to relate oxygen saturation to short and long term neurodevelopmental outcomes and to relate renal oxygen saturation to incidence of ECMO related renal failure. Near-infrared spectroscopy (NIRS) is a non-invasive technique that can be used to compute the oxygen saturation for blood in certain tissues. The regional cerebral oxygen saturation index (rSO2i) represents the weighted average of the oxygen saturation of the arteries, venules, and capillaries in certain regions of the brain. We will use this technology to monitor the cerebral blood oxygen saturation of our patients from birth until they go on ECMO, while they are on ECMO, during any surgical repair of defects (whether on ECMO at the time or not), and while the patients are being weaned from ECMO. NIRS data will also be collected from a control group of ECMO candidate neonates that are not placed on ECMO. After the patients have recovered, are off of mechanical ventilation, and are progressing well, a brain MRI is typically performed prior to discharge. The findings of these MRIs as well as the findings of neurological and neurodevelopmental examinations made at six months and one year of age will be analyzed.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 体外膜氧合（ECMO）是一种接受威胁生命疾病的新生儿（例如diaphragragragmatic Hernia），新生儿和严重先天性心脏病的肺动脉高压的接受疗法。 这些患者有脑灌注和/或ECMO期间肾衰竭的风险。 通过多种间接估计，组织灌注在这些患者中的疗效意味着组织乳酸含量，酸中毒，血液气参数等。 这项观察性研究的主要目的是评估一个脑半球可能损害的双侧脑充氧，即单侧颈动脉连接或大型静脉插管。 此外，我们希望将氧饱和度与短期和长期神经发育结果，并将肾脏氧饱和度与ECMO相关肾衰竭的发生率相关联。 近红外光谱（NIRS）是一种非侵入性技术，可用于计算某些组织中血液的氧饱和度。 区域大脑氧饱和指数（RSO2I）代表大脑某些区域中动脉，静脉和毛细血管的氧饱和度的加权平均值。 我们将使用这项技术来监测患者从出生到ECMO的患者的脑血氧饱和度，直到他们使用ECMO，在任何缺陷的手术修复期间（无论是否在ECMO上）以及患者从ECMO断奶时。 NIRS数据还将从未放置在ECMO上的ECMO候选新生儿对照组中收集。 恢复患者后，没有机械通气，并且进展顺利，通常在出院前进行大脑MRI。 这些MRI的发现以及在六个月和一岁时进行的神经和神经发育检查的发现。