BIOINFORMATICS CORE

生物信息学核心

• 批准号: 8245734
• 负责人: Li Jia
• 金额: $ 4.96万
• 依托单位: WICHITA STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8245734
• 关键词: Administrator; Aging; Amino Acid Sequence; Budgets; Cities; Computer Security; Core Facility; Critiques; Data; Databases; Dependence; Deposition; Development; Elements; Funding; Glycopeptides; Goals; Hour; Information Services; Institution; Internet; Ions; Kansas; Laboratories; Linux; Maintenance; Mass Spectrum Analysis; Medical center; Monitor; Nebraska; Online Systems; Participant; Peptide Sequence Determination; Peptides; Preparation; Principal Investigator; Protein Chemistry; Regrets; Research; Research Personnel; System; Technology; Universities; Wichita; Work; cost; data management; data sharing; design; graduate student; instrument; pituitary gonadal axis; platform-independent; programs; relational database; response; web based interface; web interface; web site

The goal is to develop a web-based data management system to facilitate the aging pituitary-gonadal axis research to be undertaken by three laboratories at three institutions in Kansas and Nebraska: Dr. George Bousfield's laboratory at WSU, Dr. T. Rajendra Kumar's laboratory at KUMC-Kansas City, and Dr. John Davis1 laboratory at the Nebraska Medical Center, Omaha, Nebraska. The proposed system will consist of two major components: one is a MySQL database, the other is a web interface for the database. Thus, the following two specific aims are focusing on the development of these two components respectively. 1. Design and implement a MySQL relational database to enable data sharing among laboratories. Using a database to support efficient data sharing among physically disparate laboratories is a critical element of this project. For instance, the dependence of glycopeptide ion identification in Project 2 will rely, in part, on the identification of the peptide moieties by protein sequencing which will be undertaken by Core B, the Protein Chemistry Core. In addition it will be necessary to transmit large amounts of mass spectrometry data from Project 2 to the laboratory that generates glycopeptide preparations in Project 1. The proposed database will facilitate data sharing by regular deposition of data produced by all participants in the project. 2. Design a web-based interface to enable users to access the database over the internet. The web-based interface will be implemented using the ASP.NET and powered by the Internet Information Services (IIS) web server. As the interface will be designed to be platform independent, data obtained from all instruments employed in this researchcan be deposited into the database and accessed by all the participating labs.

目标是开发一个基于网络的数据管理系统，以促进垂体-性腺的老化 轴研究将由堪萨斯州和内布拉斯加州三个机构的三个实验室进行：博士。 华盛顿州立大学 (WSU) 的乔治·布斯菲尔德 (George Bousfield) 实验室、堪萨斯城 KUMC 的 T. Rajendra Kumar 博士的实验室以及 内布拉斯加州奥马哈内布拉斯加州医疗中心的约翰·戴维斯实验室。拟议的系统将包括 由两个主要组件组成：一个是 MySQL 数据库，另一个是数据库的 Web 界面。因此， 以下两个具体目标分别侧重于这两个组件的开发。 1. 设计并实现MySQL关系数据库，实现实验室之间的数据共享。 使用数据库支持物理上不同的实验室之间有效的数据共享是至关重要的 该项目的元素。例如，项目 2 中糖肽离子鉴定的依赖性将依赖于， 部分，关于通过蛋白质测序鉴定肽部分，这将由 Core B 进行， 蛋白质化学核心。此外，还需要传输大量的质谱数据 将项目 2 的数据传输至项目 1 中生成糖肽制剂的实验室。 数据库将通过定期存放项目所有参与者产生的数据来促进数据共享。 2. 设计一个基于Web 的界面，使用户能够通过Internet 访问数据库。 基于 Web 的界面将使用 ASP.NET 实现并由 Internet 提供支持 信息服务 (IIS) Web 服务器。由于界面将设计为独立于平台，数据 从本研究中使用的所有仪器获得的数据可以存入数据库并通过以下方式访问 所有参与的实验室。