BIOINFORMATICS CORE

生物信息学核心

• 批准号: 8245734
• 负责人: Li Jia
• 金额: $ 4.96万
• 依托单位: WICHITA STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8245734
• 关键词: Administrator; Aging; Amino Acid Sequence; Budgets; Cities; Computer Security; Core Facility; Critiques; Data; Databases; Dependence; Deposition; Development; Elements; Funding; Glycopeptides; Goals; Hour; Information Services; Institution; Internet; Ions; Kansas; Laboratories; Linux; Maintenance; Mass Spectrum Analysis; Medical center; Monitor; Nebraska; Online Systems; Participant; Peptide Sequence Determination; Peptides; Preparation; Principal Investigator; Protein Chemistry; Regrets; Research; Research Personnel; System; Technology; Universities; Wichita; Work; cost; data management; data sharing; design; graduate student; instrument; pituitary gonadal axis; platform-independent; programs; relational database; response; web based interface; web interface; web site

The goal is to develop a web-based data management system to facilitate the aging pituitary-gonadal axis research to be undertaken by three laboratories at three institutions in Kansas and Nebraska: Dr. George Bousfield's laboratory at WSU, Dr. T. Rajendra Kumar's laboratory at KUMC-Kansas City, and Dr. John Davis1 laboratory at the Nebraska Medical Center, Omaha, Nebraska. The proposed system will consist of two major components: one is a MySQL database, the other is a web interface for the database. Thus, the following two specific aims are focusing on the development of these two components respectively. 1. Design and implement a MySQL relational database to enable data sharing among laboratories. Using a database to support efficient data sharing among physically disparate laboratories is a critical element of this project. For instance, the dependence of glycopeptide ion identification in Project 2 will rely, in part, on the identification of the peptide moieties by protein sequencing which will be undertaken by Core B, the Protein Chemistry Core. In addition it will be necessary to transmit large amounts of mass spectrometry data from Project 2 to the laboratory that generates glycopeptide preparations in Project 1. The proposed database will facilitate data sharing by regular deposition of data produced by all participants in the project. 2. Design a web-based interface to enable users to access the database over the internet. The web-based interface will be implemented using the ASP.NET and powered by the Internet Information Services (IIS) web server. As the interface will be designed to be platform independent, data obtained from all instruments employed in this researchcan be deposited into the database and accessed by all the participating labs.

目标是开发一个基于网络的数据管理系统，以促进垂体性腺的老化 AXIS研究将由堪萨斯州和内布拉斯加州的三个机构的三个实验室进行： 乔治·布斯菲尔德在华盛顿州立大学的实验室，T·拉金德拉·库马尔博士在堪萨斯城库马尔大学的实验室。 内布拉斯加州奥马哈市内布拉斯加州医疗中心的约翰·戴维斯实验室。拟议的系统将包括 两个主要组件中的一个：一个是MySQL数据库，另一个是数据库的Web界面。因此， 以下两个具体目标分别侧重于这两个组成部分的发展。 1.设计并实现了MySQL关系数据库，实现了实验室间的数据共享。 使用数据库在物理上不同的实验室之间支持高效的数据共享是至关重要的 这个项目的要素。例如，项目2中的糖肽离子鉴定的依赖性将依赖于 部分，关于将由核心B进行的通过蛋白质测序来鉴定多肽部分， 蛋白质化学核心。此外，还需要传输大量的质谱图 从项目2到项目1中生产糖肽制剂的实验室的数据。建议的 数据库将通过定期存放项目所有参与方产生的数据来促进数据共享。 2.设计基于Web的界面，使用户能够通过Internet访问数据库。 基于网络的界面将使用ASP.NET实现，并由互联网提供支持 信息服务(IIS)Web服务器。由于接口将被设计为独立于平台、数据 从这项研究中使用的所有仪器获得的数据可以存入数据库，并由 所有参与的实验室。