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Sphingolipid mediators in atherogenesis

Sphingolipid mediators in atherogenesis
动脉粥样硬化形成中的鞘脂介质
批准号：
8150050
负责人：
Timothy Tun Hla
金额：
$48.8万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-07-01 至 2014-06-30
来源：
https://reporter.nih.gov/project-details/8150050
关键词：
AccountingAddressAnti-Inflammatory AgentsAnti-inflammatoryApolipoprotein EAreaArterial Fatty StreakArteriesAtherosclerosisAttenuatedAutocrine CommunicationBiochemicalBlood VesselsBone MarrowBone Marrow TransplantationCaspaseCell membraneCellsCholesterolCholesterol HomeostasisCoagulation ProcessComplexDataDendritic CellsDevelopmentDominant-Negative MutationEtiologyExhibitsGTP-Binding ProteinsGene ExpressionGenesH218 ProteinHeart DiseasesHematopoieticHematopoietic stem cellsHigh Density LipoproteinsHumanHypoxiaImmune systemInflammationInflammatoryInflammatory ResponseInstructionInterleukin-18Knockout MiceKnowledgeLaboratoriesLeadLipoproteinsMediatingMediator of activation proteinMembrane MicrodomainsMessenger RNAMetabolismModelingMolecularMusMyelogenousMyeloid CellsMyocardial InfarctionNew AgentsPTEN genePathogenesisPathologicPathway interactionsPeptide HydrolasesPhenotypePhospholipidsPhosphoric Monoester HydrolasesPlasmaProductionReceptor SignalingRegulationRoleSignal TransductionSphingolipidsSphingomyelinaseSphingomyelinsSphingosine-1-Phosphate ReceptorStem cellsStimulusSystemTestingTherapeuticTranslational RegulationVascular DiseasesVascular PermeabilitiesVascular SystemWorkatherogenesisbasecytokineessential phospholipidsexpression vectorin vivolipid mediatormacrophagemouse modelmutantnovelnovel strategiesreceptorreceptor couplingresearch studyresponseretinal angiogenesisrhorho GTP-Binding Proteinssphingosine 1-phosphatesphingosine kinasetooltraffickingvascular inflammation

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