CORE--Physiology-Animal

核心--生理学-动物

• 批准号: 8133516
• 负责人: You-Tang Shen
• 金额: $ 58.84万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8133516
• 关键词: Adult; Animal Husbandry; Animal Model; Animals; Breeding; Caring; Chronic; Databases; Echocardiography; Family suidae; Genotype; Goals; Health; Heart Diseases; Housing; Human Resources; Laboratory Animal Production and Facilities; Maintenance; Mus; Muscle Cells; Neonatal; New Jersey; Operative Surgical Procedures; Physiology; Preparation; Rattus; Rodent Model; Services; Surgical Models; Transgenic Mice; animal care; cost; feeding; hemodynamics; instrument; medical schools; meetings; mouse model

Core B, the Physiology/Animal Care Core, will provide services related to the preparation of animal models used in the PPG including surgical preparation of the various pig, and mouse models and the health maintenance of these chronic animal preparations. Animal husbandry, including normal housing and feeding, will be carried out by the Research Animal Facility of UMDNJ - New Jersey Medical School. There are four major functions of Core B. The first component of Core B involves surgical preparation of the large animal models, which is required for Projects 1 and 2. The second component involves surgical preparation of the rodent models, which is required for Projects 3 and 4. In the third component, Core B will provide the animal care required for the animal models, including both the care required for maintaining health in chronically instrumented animals and maintenance of the breeding colonies of transgenic mice. The fourth function is administration, since this core services all projects and interacts closely with the other cores, and must meet the regulatory requirements for animal care. The breakdown is as follows: Projects 1 and 2 will use domestic swine (25 % of Core activity, but 30% of Core costs, for each project), Project 3 will use transgenic mice (30% of Core activity, but 25% of Core costs) (rats will be used for neonatal and adult myocyte culture), Project 4 will use transgenic mice (20% of Core activity, but 15% of Core costs).

核心B，即生理学/动物护理核心，将提供与制备用于研究的动物模型相关的服务。 PPG包括各种猪的手术准备，以及小鼠模型和这些慢性的健康维护 动物制剂。动物饲养，包括正常的住房和喂养，将由研究 UMDNJ -新泽西医学院动物机构。核心B有四个主要功能。第一部件 核心B涉及大型动物模型的手术准备，这是项目1和2所需的。第二 项目3和项目4需要对啮齿动物模型进行手术准备。第三 核心B将提供动物模型所需的动物护理，包括 维持长期使用仪器的动物的健康和维持转基因小鼠的繁殖群体。 第四个功能是管理，因为这个核心服务于所有项目，并与其他核心密切互动， 必须符合动物护理的法规要求。细目如下：项目1和2将使用 项目3将使用转基因小鼠（占每个项目核心活动的25%，但占核心成本的30%），项目3将使用转基因小鼠（占30%）。 核心活动，但核心成本的25%）（大鼠将用于新生儿和成人肌细胞培养），项目4将使用 转基因小鼠（核心活性的20%，但核心成本的15%）。