NOVEL EPITOPES THAT MEDIATE BROAD NEUTRALIZATION OF CLADE B AND C HIV-1 ISOLATES
NOVEL EPITOPES THAT MEDIATE BROAD NEUTRALIZATION OF CLADE B AND C HIV-1 ISOLATES
批准号:
8357473
负责人:
Cynthia Ann Derdeyn
金额:
$3.72万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-08-01 至 2012-04-30
关键词:
AntibodiesAutologousB-LymphocytesEpitope MappingEpitopesFundingGlycoproteinsGrantHIV-1MasksMediatingMonoclonal AntibodiesNational Center for Research ResourcesPatientsPlasmaPrimatesPrincipal InvestigatorProcessResearchResearch InfrastructureResistanceResourcesSamplingSerumSourceUnited States National Institutes of HealthVaccinesViralcostimmunogenicinterestneutralizing antibodynovelresponse
中文摘要
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Progress towards an HIV-1 vaccine has been stymied by the inability to induce a protective humoral response. Well-characterized neutralization epitopes are either poorly immunogenic or effectively masked on the majority of patient isolates. Newer evidence suggests that even highly masked primary isolates possess sensitive neutralization targets that are recognized by autologous patient sera and occasionally by heterologous sera. This suggests that mapping the epitopes involved may identify novel targets that are capable of inducing broadly neutralizing activities. In this project, we are identifying subtype B and C infected patients that possess broadly neutralizing activities for primary isolates, and localize the target epitopes.
We are interested in antibody activities that mediate potent neutralization of heterologous viral envelope (Env) glycoproteins from various subtypes. We screened more than 100 plasma samples from subtype C HIV-1 for cross-neutralizing activities against heterologous Envs in order to discover novel targets that are exposed on typical neutralization-resistant primary isolates. In the past funding period, we identified a subtype C infected subject whose plasma possesses exceptional breadth and potency. We are in the process of characterizing the autologous viral Env and antibody neutralizing activity in this patient, as well as generating monoclonal antibodies from B cells.
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会议论文
Interplay of the HIV-1 Env cytoplasmic tail, Gag-MA, and membrane: resolving molecular detail and blocking assembly
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批准号:10772333
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项目类别:
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资助金额:$82.76万
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财政年份:2023
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负责人:Cynthia Ann Derdeyn
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依托单位:
Tracking the evolutionary trajectory of neutralizing antibodies following BG505 SOSIP immunization
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批准号:10620979
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项目类别:
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资助金额:$82.28万
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财政年份:2023
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负责人:Cynthia Ann Derdeyn
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依托单位:
Novel treatment for respiratory distress due to SARS-CoV2 infection
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批准号:10284733
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项目类别:
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资助金额:$23.46万
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财政年份:2021
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负责人:Cynthia Ann Derdeyn
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依托单位:
Novel treatment for respiratory distress due to SARS-CoV2 infection
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批准号:10426353
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项目类别:
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资助金额:$19.56万
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财政年份:2021
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负责人:Cynthia Ann Derdeyn
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依托单位:
Discovery of Novel Epitopes for Antibody Dependent Cell-mediated Cytotoxicity Against HIV-1 Infected Cells
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批准号:10031027
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项目类别:
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资助金额:$26.78万
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财政年份:2020
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负责人:Cynthia Ann Derdeyn
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依托单位:
Discovery of Novel Epitopes for Antibody Dependent Cell-mediated Cytotoxicity Against HIV-1 Infected Cells
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批准号:10113530
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项目类别:
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资助金额:$22.31万
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财政年份:2020
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负责人:Cynthia Ann Derdeyn
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依托单位:
Antibody Effector Function and Virology
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批准号:8516873
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项目类别:
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资助金额:$54.17万
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财政年份:2013
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负责人:Cynthia Ann Derdeyn
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依托单位:
Antibody Effector Function and Virology
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批准号:8326368
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项目类别:
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资助金额:$53.37万
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财政年份:2011
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负责人:Cynthia Ann Derdeyn
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依托单位:
ANTIBODY NEUTRALIZATION AND ESCAPE IN SUBTYPE C HIV-1
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批准号:8357423
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项目类别:
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资助金额:$7.43万
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财政年份:2011
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负责人:Cynthia Ann Derdeyn
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依托单位:
NOVEL EPITOPES THAT MEDIATE BROAD NEUTRALIZATION OF CLADE B AND C HIV-1 ISOLATES
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批准号:8172428
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项目类别:
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资助金额:$2.74万
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财政年份:2010
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负责人:Cynthia Ann Derdeyn
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依托单位:
ANTIBODY NEUTRALIZATION AND ESCAPE IN SUBTYPE C HIV-1
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批准号:8172357
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项目类别:
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资助金额:$5.48万
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财政年份:2010
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负责人:Cynthia Ann Derdeyn
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依托单位:
ANTIBODY NEUTRALIZATION AND ESCAPE IN SUBTYPE C HIV-1
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批准号:7958165
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项目类别:
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资助金额:$5.67万
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财政年份:2009
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负责人:Cynthia Ann Derdeyn
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依托单位:
NOVEL EPITOPES THAT MEDIATE BROAD NEUTRALIZATION OF CLADE B AND C HIV-1 ISOLATES
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批准号:7958254
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项目类别:
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资助金额:$2.84万
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财政年份:2009
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负责人:Cynthia Ann Derdeyn
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依托单位:
ROLE OF V1V2 IN HIV TENASMISSION AND PATHOGENESIS
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批准号:7715739
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项目类别:
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资助金额:$6.8万
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财政年份:2008
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负责人:Cynthia Ann Derdeyn
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依托单位:
ROLE OF V1V2 IN HIV TENASMISSION AND PATHOGENESIS
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批准号:7562594
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项目类别:
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资助金额:$6.55万
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财政年份:2007
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负责人:Cynthia Ann Derdeyn
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依托单位:
ROLE OF V1V2 IN HIV TENASMISSION AND PATHOGENESIS
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批准号:7349255
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项目类别:
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资助金额:$5.97万
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财政年份:2006
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负责人:Cynthia Ann Derdeyn
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依托单位:
ROLE OF V1V2 IN HIV TENASMISSION AND PATHOGENESIS
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批准号:7166012
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项目类别:
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资助金额:$5.24万
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财政年份:2005
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负责人:Cynthia Ann Derdeyn
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依托单位:
Antibody Neutralization and Escape of Subtype C HIV-1
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批准号:7769461
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项目类别:
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资助金额:$43.56万
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财政年份:2004
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负责人:Cynthia Ann Derdeyn
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依托单位:
Determinants of Neutralization Breadth in Early HIV-1 Infection
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批准号:8541334
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项目类别:
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资助金额:$80.23万
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财政年份:2004
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负责人:Cynthia Ann Derdeyn
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依托单位:
Determinants of Neutralization Breadth in Early HIV-1 Infection
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批准号:8842576
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项目类别:
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资助金额:$82.07万
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财政年份:2004
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负责人:Cynthia Ann Derdeyn
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依托单位:
海外基金