ENHANCEMENT OF LUMBAR FUSION W/ RHBMP 2/ COLLAGEN OR LMP
使用 RHBMP 2/胶原蛋白或 LMP 增强腰椎融合
基本信息
- 批准号:8357373
- 负责人:
- 金额:$ 3.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-08-01 至 2012-04-30
- 项目状态:已结题
- 来源:
- 关键词:AnimalsBone TransplantationCeramicsCollagenComplicationCytoplasmic GranulesDoseFailureFundingGenetic EngineeringGrantGrowth FactorHealedHumanMacaca mulattaModelingNational Center for Research ResourcesOperative Surgical ProceduresOryctolagus cuniculusOsteogenesisPreparationPrimatesPrincipal InvestigatorRecombinantsReportingResearchResearch InfrastructureResistanceResourcesSiteSourceSpeedSpinal FusionTestingTitaniaTitaniumUnited States National Institutes of HealthVertebral columnbonebone morphogenetic protein 2costhealingminimally invasivenonhuman primate
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Lumbar spinal fusion is commonly performed on humans, but the failure of bone union is a frequent complication. Osteoinductive growth factors synthesized by recombinant DNA technology have been shown to induce bone formation in heterotopic sites. Recombinant human BMP-2 (rhBMP-2) has been effective in generating spine fusions in a rabbit model. To determine the dose of the growth factor in humans, and to determine the speed of healing, a nonhuman primate model is used. In 2010, we did surgery on 4 rhesus monkeys to investigate a new ceramic bone graft substitute. Higher doses than expected were required to make bone in the primate. The growth factor was delivered inside a hollow titanium treated fusion cage through a minimally invasive approach. Studies have focused on fine tuning the dose and studying alternative carrier materials, including different combinations of ceramic materials for use in the posterolateral spine. We investigated new carriers for BMP-2 and continued studies with LMP-1, and we found that a compression resistant collagen matrix was an effective carrier. During the reporting period, we tested wrapping the existing BMP-w preparation around a ceramic granule matrix as a bulking agent. This was successful in 2/3s animals to achieve spine fusion. This will move on to human trials.
这个子项目是利用这些资源的众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SCOTT D. BODEN其他文献
SCOTT D. BODEN的其他文献
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{{ truncateString('SCOTT D. BODEN', 18)}}的其他基金
Small Molecule Inhibition of Noggin to Induce Spinal Fusion
Noggin 的小分子抑制诱导脊柱融合
- 批准号:
10666349 - 财政年份:2022
- 资助金额:
$ 3.29万 - 项目类别:
Small Molecule Inhibition of Noggin to Induce Spinal Fusion
Noggin 的小分子抑制诱导脊柱融合
- 批准号:
10367281 - 财政年份:2022
- 资助金额:
$ 3.29万 - 项目类别:
ENHANCEMENT OF LUMBAR FUSION W/ RHBMP 2/ COLLAGEN OR LMP
使用 RHBMP 2/胶原蛋白或 LMP 增强腰椎融合
- 批准号:
8172300 - 财政年份:2010
- 资助金额:
$ 3.29万 - 项目类别:
ENHANCEMENT OF LUMBAR FUSION W/ RHBMP 2/ COLLAGEN OR LMP
使用 RHBMP 2/胶原蛋白或 LMP 增强腰椎融合
- 批准号:
7958099 - 财政年份:2009
- 资助金额:
$ 3.29万 - 项目类别:
ENHANCEMENT OF LUMBAR FUSION W/ RHBMP 2/ COLLAGEN OR LMP
使用 RHBMP 2/胶原蛋白或 LMP 增强腰椎融合
- 批准号:
7715661 - 财政年份:2008
- 资助金额:
$ 3.29万 - 项目类别:
ENHANCEMENT OF LUMBAR FUSION W/ RHBMP 2/ COLLAGEN OR LMP
使用 RHBMP 2/胶原蛋白或 LMP 增强腰椎融合
- 批准号:
7562496 - 财政年份:2007
- 资助金额:
$ 3.29万 - 项目类别:
ENHANCEMENT OF LUMBAR FUSION W/ RHBMP 2/ COLLAGEN OR LMP
使用 RHBMP 2/胶原蛋白或 LMP 增强腰椎融合
- 批准号:
7349127 - 财政年份:2006
- 资助金额:
$ 3.29万 - 项目类别:
LMP-1 is a critical regulator of BMP signaling and BMP responsiveness
LMP-1 是 BMP 信号传导和 BMP 反应性的关键调节因子
- 批准号:
7798565 - 财政年份:2006
- 资助金额:
$ 3.29万 - 项目类别:
LMP-1 is a critical regulator of BMP signaling and BMP responsiveness
LMP-1 是 BMP 信号传导和 BMP 反应性的关键调节因子
- 批准号:
7012602 - 财政年份:2006
- 资助金额:
$ 3.29万 - 项目类别:
LMP-1 is a critical regulator of BMP signaling and BMP responsiveness
LMP-1 是 BMP 信号传导和 BMP 反应性的关键调节因子
- 批准号:
7596867 - 财政年份:2006
- 资助金额:
$ 3.29万 - 项目类别:
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