A development of the way of bone transplantation using adipose derived stem cells

利用脂肪干细胞进行骨移植的方法的进展

• 批准号: 23792037
• 负责人: AKITA Shinsuke
• 金额: $ 2.58万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792037/
• 关键词: 脂肪由来幹細胞; 骨髄由来幹細胞; 骨延長術; 脂肪由来間葉系幹細胞; 骨髄由来間葉系幹細胞; 顎骨骨延長

We planned to examine whether adipose derived stem cells (ADSC) could surpass bone marrow derived stem cells (BMSC) for donor ability. Both of them were inducted in osteoinduction medium within scaffolds, and transferred into bone defect respectively that we made on rabbits' mandible. After 4weeks, we harvested the tissues, both of defects showed less fibrosis compared with control group, but we didn't detect significant differences between them statistically. Moreover neither of ADSC nor MSC provided more bone remodeling than controls. That lead us to the investigation that we should consider the term for osteo-induction in vitro and the fact transfer groups prevented defect fibrosis means this methods could be an effective step to prevent bone regression in clinical cases after osteodistruction surgery of infants suffering midface anomary.

我们计划检查脂肪来源的干细胞（ADSC）是否可以超过骨髓来源的干细胞（BMSC）的供体能力。两种材料均在支架内的骨诱导液中诱导，并分别移植到兔下颌骨缺损处。4周后取组织，两组缺损区纤维化程度均较对照组轻，但差异无统计学意义。此外，ADSC和MSC都没有比对照组提供更多的骨重建。这导致我们的调查，我们应该考虑在体外骨诱导的术语和事实转移组防止缺损纤维化意味着这种方法可能是一个有效的步骤，以防止骨退行性疾病的婴儿面中部畸形的骨扩张手术后的临床病例。