Effect of tendon damage accumulation on healing and adaptation

描述（由申请人提供）：肌腱损伤累积和肌腱撕裂是肌肉骨骼残疾的主要来源，困扰着整个社会。尽管这些问题的重要性，临床医生几乎没有治疗建议的科学依据，因为运动可以改善肌腱内环境稳定和抗损伤的机制，疲劳损伤肌腱愈合不良的机制，以及活动对修复的患病肌腱愈合的影响尚不清楚。以前的研究调查了运动和撕裂的影响，但仅限于健康肌腱。我们已经开发和广泛的特点在大鼠髌腱疲劳损伤积累的体内模型，现在建议研究疲劳损伤肌腱运动和/或撕裂的反应。这些研究，使用这种临床相关的模型患病肌腱，将提供新的和改进的治疗策略的基础。 公共卫生相关性：本研究的主要目的是探讨肌腱过度使用损伤对肌腱细胞运动和撕裂反应的影响。成功完成拟议的研究将为肌腱损伤的新的和改进的治疗策略提供基础。

DESCRIPTION (provided by applicant): Damage accumulation in tendons and tendon tears are a major source of musculoskeletal disability, afflicting the entire spectrum of society. Despite the importance of these problems, clinicians have little scientific basis for treatment recommendations because mechanisms whereby exercise may improve tendon homeostasis and resistance to injury, mechanisms responsible for the poor healing of fatigue damaged tendons, and the effect of activity on the healing of repaired diseased tendons are unknown. Previous studies have investigated the effects of exercise and laceration, but only in healthy tendon. We have developed and extensively characterized an in vivo model of fatigue damage accumulation in the rat patellar tendon, and now propose to study the response of fatigue damaged tendon to exercise and/or laceration. These studies, using this clinically relevant model of diseased tendons, will provide the foundation for novel and improved treatment strategies. PUBLIC HEALTH RELEVANCE: The major goal of this project is to explore the effect of tendon overuse damage on the response of tenocytes to exercise and laceration. Successful completion of the proposed studies will provide the foundation for novel and improved treatment strategies for tendon injury.