VASCULAR SENSOR FOR WOMEN'S REPRODUCTIVE HEALTH RESEARCH

用于女性生殖健康研究的血管传感器

• 批准号: 8057783
• 负责人: Wendelin L. Sachtler
• 金额: $ 14.72万
• 依托单位: CORPORA SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-24 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8057783
• 关键词: Address; Adverse drug effect; American; Antidepressive Agents; Basic Science; Behavior Therapy; Biofeedback; Blood Vessels; Blood flow; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Clinical assessments; Clip; Clitoris; Collaborations; Diabetes Mellitus; Diagnosis; Disease; Evaluation Studies; Female; Foundations; Gender; Genital system; Home environment; Incidence; Indiana; Intervention; Investigation; Light; Marketing; Measurement; Measures; Medical; Mental Depression; Methods; Morphologic artifacts; Motion; Multiple Sclerosis; Outcome; Patients; Pharmaceutical Preparations; Phase; Physiologic pulse; Physiological; Physiological Processes; Physiology; Plastics; Privacy; Procedures; Process; Reading; Reproducibility; Reproduction; Reproductive Health; Research; Research Institute; Role; Sampling; Sex Functioning; Sexual Dysfunction; Sexual Health; Signal Transduction; Small Business Innovation Research Grant; Structure; System; Therapeutic; Therapeutic procedure; Time; Tissues; Universities; Vagina; Vascular blood supply; Woman; Work; blood flow measurement; design; flexibility; hypertensive heart disease; indexing; instrument; men; nerve supply; novel; novel diagnostics; novel therapeutics; prototype; response; sensor; sex; success; validation studies

DESCRIPTION (provided by applicant): It is estimated that around 45-60 million American women suffer from sexual disorders at some point in their lives. In comparison, about 30 million men are afflicted with comparable conditions. In both men and women, sexual disorders can be associated with a number of clinical conditions, including diabetes, heart disease, hypertension, multiple sclerosis, and depression. The assessment of the physiology of sexual response is of fundamental importance to research on sexual function and dysfunction. The most widely used approach to the measurement of sexual response involves the assessment of vascular activity in genital tissue. In women, research has largely focused on vaginal blood flow-not primarily because of its central role in female sexual response, but because instruments are readily available and easy to use, unlike current instruments for measurement of clitoral blood flow. However, studies of vaginal blood flow have found no consistent difference between women with and women without sexual disorders. In contrast, recent evidence suggests that clitoral vascular responses are reduced in women with sexual disorders. These results point at the need for new clinical assessment methods for women<s sexual health, though current measurement methods are unreliable, limited, or impractical for general clinical and research use. The proposed project will develop the first practical means of stable sensor placement to enable reliable and practical measurement of clitoral blood flow. The project will also include an evaluation study to simultaneously measure and compare vaginal and clitoral responses. The instrument can be expected to be of fundamental importance to diagnosis, treatment, and research of sexual disorders in women, including basic research on the physiology of sexual function and disorders, clinical investigations of treatments for sexual disorders, and investigations on the side effects of drugs such as antidepressants on sexual health. Due to its ease of use, the clip also has significant potential for therapeutic application in the privacy of a patient<s home, such as for biofeedback, sensate focus, drug treatment, or other medical and behavioral interventions. PUBLIC HEALTH RELEVANCE: Approximately 45-60 million American women suffer from sexual disorders at some point in their lives, but progress in diagnosis and treatment is hindered in part by a lack of valid approaches to the measurement of relevant physiological processes. The proposed project will develop a new instrument that will enable important research on such processes and has the potential to become the method of choice for novel diagnostic and therapeutic procedures.

描述（由申请人提供）：据估计，大约有45-60万美国妇女患有性功能障碍，在某些时候在他们的生活。相比之下，约有3000万男性患有类似的疾病。在男性和女性中，性功能障碍可能与许多临床疾病有关，包括糖尿病、心脏病、高血压、多发性硬化症和抑郁症。性反应生理学的评估对于性功能和性功能障碍的研究具有根本的重要性。最广泛使用的测量性反应的方法包括评估生殖器组织中的血管活动。在女性中，研究主要集中在阴道血流量上，这并不主要是因为它在女性性反应中的核心作用，而是因为仪器容易获得且易于使用，不像目前用于测量阴蒂血流量的仪器。然而，对阴道血流的研究发现，患有性功能障碍的女性和没有性功能障碍的女性之间没有一致的差异。与此相反，最近的证据表明，阴蒂血管反应减少性功能障碍的妇女。这些结果表明，需要新的临床评估方法来评估妇女的性健康，尽管目前的测量方法对于一般的临床和研究使用是不可靠的，有限的或不切实际的。拟议的项目将开发第一种实用的稳定传感器放置方法，以实现可靠和实用的阴蒂血流测量。该项目还将包括一项评估研究，以同时测量和比较阴道和阴蒂的反应。可以预期，该仪器对妇女性功能障碍的诊断、治疗和研究具有根本重要性，包括性功能和性障碍生理学的基础研究、性功能障碍治疗的临床研究以及抗抑郁药等药物对性健康的副作用的研究。由于其易于使用，该夹子还具有在患者家中的隐私中的治疗应用的显著潜力，例如用于生物反馈、感觉焦点、药物治疗或其他医疗和行为干预。 公共卫生相关性：大约有4500万至6000万美国妇女在生活中的某个时候患有性功能障碍，但由于缺乏有效的方法来测量相关的生理过程，诊断和治疗的进展受到了部分阻碍。拟议的项目将开发一种新的仪器，使对这些过程的重要研究成为可能，并有可能成为新的诊断和治疗程序的首选方法。

项目成果

The Successful Measurement of Clitoral Pulse Amplitude Using a New Clitoral Photoplethysmograph: A Pilot Study.

使用新型阴蒂光电体积描记器成功测量阴蒂脉冲幅度：一项试点研究。

• DOI: 10.1016/j.jsxm.2020.02.017
• 发表时间: 2020
• 期刊: The journal of sexual medicine
• 作者: Mechelmans,DaisyJ;Sachtler,WendelinL;vonWiegand,ThomasE;Goodrich,David;Heiman,JuliaR;Janssen,Erick
• 通讯作者: Janssen,Erick