Online patient self-assessment for chronic pancreatic and other pain

在线患者自我评估慢性胰腺疼痛和其他疼痛

• 批准号: 8203244
• 负责人: Andrew H. Soll
• 金额: $ 39.78万
• 依托单位: CPM SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8203244
• 关键词: Abbreviations; Anxiety Disorders; Behavioral; Caring; Chronic; Clinic; Clinical; Clinical Trials; Cognitive; Collection; Communication; Computers; Consensus; Data; Data Reporting; Diagnosis; Dimensions; Disadvantaged; Elements; Ensure; Etiology; Feedback; Fostering; Foundations; Funding; Generations; Generic Drugs; Goals; Health; Home environment; Hypersensitivity; Individual; Inflammation; Internet; Interview; Intractable Pain; Investigation; Judgment; Light; Literature; Logic; Measures; Medical; Mental Depression; Modeling; Natural History; Nervous system structure; Obstruction; Online Systems; Outcome; Pain; Pain Measurement; Pancreas; Pancreatic Diseases; Pathway interactions; Patient Care; Patient Self-Report; Patient-Centered Care; Patients; Performance; Phase; Physicians; Process; Quality of Care; Quality of life; Recording of previous events; Reporting; Research; Research Personnel; Research Support; Resources; Rest; Review Literature; Risk; Risk Assessment; Screening procedure; Self Assessment; Severities; Signal Transduction; Site; Sleep disturbances; Small Business Innovation Research Grant; Smoking; Social support; Stress; Structure; Support System; Symptoms; System; Testing; Thinking; Time; Trauma; Triage; United States National Institutes of Health; Visceral; Work; alcohol misuse; allodynia; base; biopsychosocial; central sensitization; chronic pain; chronic pancreatitis; clinical phenotype; cost effectiveness; disability; effective therapy; experience; improved; instrument; meetings; painful neuropathy; psychologic; psychosocial; research in practice; response; routine care; social; stem; tool; treatment response

DESCRIPTION (provided by applicant): The pain associated with chronic pancreatitis is challenging to treat and to investigate. Chronic pancreatic pain (CPP) reflects multiple potential mechanisms: visceral factors (e.g., obstruction, inflammation), neuropathic pain due to central sensitization, and psychosocial and behavioral factors (e.g., depression, anxiety disorders, trauma or abuse, poorly tolerated stress, and poor social support). Smoking and alcohol misuse contribute both to the pain and the chronic pancreatitis. Despite a recognized need, no practical, integrated assessment tools are available to gather and track a comprehensive assessment for either patient care or research. Therefore, physicians and investigators are often looking at CPP through a pinhole. SOLUTION: Our objective is to develop an assessment for the biomedical, psychosocial, behavioral, and quality-of-life (biopsychosocial, BPS) dimensions of CPP for an existing online, branching, patient self- assessment system called CarePrep, thereby identifying patients at risk for refractory pain and disability, measuring pain's impact, illuminating mechanisms, guiding management, and tracking status and response to treatment. Moreover, our goals are to meet the needs of patients and clinicians for enhancing communication and patient-centered care, and to generate sufficient value to warrant installation in the pathway of routine care; thereby transparently capturing data for research. A preliminary, generic Online, CarePrep Assessment (OCA) is operating in clinic; it allows patients to easily enter and track BPS data over the Internet from home or clinic. The OCA is maintainable, scalable, and ready to support the proposed work. APPROACH: Aim 1) Working with experts, we will review the literature, established instruments, and current OCA content; develop a plan for a comprehensive pain assessment; and then prioritize and designate elements of a core CPP assessment of reasonable scope for Phase 1. We will deploy the system at our sites and start patient testing, gathering feedback to guide refinement. Patients will be asked to do CarePrep before clinic, and the report will be delivered to physicians before the clinic encounter. Aim 2) Focusing on core CPP content, we will assess content validity using cognitive interviews; assess construct validity using patient ratings of OCA report accuracy; and comparing OCA data to structured interviews by two evaluators, examining inter-rater reliability. Aim 3) We will use physician and patient self-reports to assess feasibility and utility. IMPACT stems from 1) creating a pandimensional, streamlined, expandable assessment that minimizes redundancy and maximizes relevance, thereby facilitating collection of the full spectrum of data useful for both patient care and research; 2) creating a BPS pain assessment resource that generates sufficient value to relevant stakeholders to warrant routine use, thereby fostering BPS care; 3) using a consensus process to create this assessment resource, thereby maximizing value for patient care and research, and 4) using the OCA installed in the pathway of routine care to transparently capture data thereby facilitating the conduct of research in practice settings. PUBLIC HEALTH RELEVANCE: This work develops an online, patient self-assessment system to support the care and clinical investigation of chronic pancreatic disease and chronic pancreatic pain in particular. A preliminary version of our online system now operating in clinic gathers a generic, comprehensive assessment. The proposed work will develop components covering medical, psychological, social, behavioral, and quality-of-life issues relevant to chronic pancreatic pain. The system will also gather clues to identify neuropathic pain, which occurs when the nervous system fails to properly regulate pain signals. Any of these factors could contribute to chronic pain, and, therefore, it is important to obtain a comprehensive assessment on all pain patients. These factors can help unravel the causes of the pain and point the way to more effective treatment. Although we focus on chronic pancreatic pain, we are using a general approach that will be applicable to any chronic pain or non-pain symptom.

描述（由申请人提供）：慢性胰腺炎相关疼痛的治疗和研究具有挑战性。慢性胰腺疼痛（CPP）反映了多种潜在机制：内脏因素（例如，阻塞，炎症），由于中枢致敏引起的神经性疼痛，以及心理社会和行为因素（例如，抑郁症、焦虑症、创伤或虐待、对压力的耐受性差和社会支持差）。吸烟和酗酒都有助于疼痛和慢性胰腺炎。尽管有公认的需求，但没有实用的综合评估工具可用于收集和跟踪患者护理或研究的综合评估。因此，医生和研究人员经常通过针孔观察CPP。解决方案：我们的目标是为现有的在线、分支、患者自我评估系统（称为CarePrep）开发对CPP的生物医学、心理社会、行为和生活质量（生物心理社会，BPS）维度的评估，从而识别患者存在难治性疼痛和残疾的风险，测量疼痛的影响，阐明机制，指导管理以及跟踪状态和治疗反应。此外，我们的目标是满足患者和临床医生的需求，以加强沟通和以患者为中心的护理，并产生足够的价值，以保证安装在常规护理的路径;从而透明地捕获数据进行研究。一个初步的，通用的在线，CarePrep评估（OCA）是在诊所操作;它允许患者轻松地输入和跟踪BPS数据通过互联网从家里或诊所。OCA是可维护的，可扩展的，并准备支持拟议的工作。方法：目标1）与专家合作，我们将审查文献、既定工具和当前OCA内容;制定全面疼痛评估计划;然后优先考虑并指定第1阶段合理范围的核心CPP评估要素。我们将在我们的站点部署该系统，并开始进行患者测试，收集反馈以指导改进。将要求患者在诊所前进行CarePrep，并在诊所就诊前将报告交付给医生。目的2）以CPP核心内容为研究对象，采用认知访谈法评估内容效度;采用患者对OCA报告准确性的评分法评估结构效度;将OCA数据与两名评估者的结构化访谈进行比较，检验评分者间的信度。目的3）我们将使用医生和患者的自我报告来评估可行性和实用性。IMPACT源于1）创建一个全维度的，精简的，可扩展的评估，最大限度地减少冗余和最大限度地提高相关性，从而促进收集对患者护理和研究有用的全方位数据; 2）创建一个BPS疼痛评估资源，为相关利益相关者产生足够的价值，以保证常规使用，从而促进BPS护理; 3）使用共识过程来创建此评估资源，从而最大化患者护理和研究的价值，以及4）使用安装在常规护理路径中的OCA来透明地捕获数据，从而促进在实践环境中进行研究。 公共卫生相关性：这项工作开发了一个在线的患者自我评估系统，以支持慢性胰腺疾病和慢性胰腺疼痛的护理和临床调查。我们的在线系统的初步版本现在在诊所运行，收集了一个通用的，全面的评估。拟议的工作将开发涵盖慢性胰腺疼痛相关的医疗，心理，社会，行为和生活质量问题的组件。该系统还将收集线索以识别神经性疼痛，当神经系统无法正确调节疼痛信号时会发生这种疼痛。这些因素中的任何一个都可能导致慢性疼痛，因此，对所有疼痛患者进行全面评估非常重要。这些因素可以帮助解开疼痛的原因，并指出更有效的治疗方法。虽然我们专注于慢性胰腺疼痛，但我们使用的是适用于任何慢性疼痛或非疼痛症状的一般方法。