A Low Power Wireless Pulse Oximeter Sensor for Unobtrusive Wearable Applications

描述(由申请人提供)：Koronis Biomedical Technology Corporation(KBT)建议开发和评估一种用于长期可穿戴监测的微型超低功率脉冲血氧仪。临床上仍然需要一种不显眼的脉搏血氧计传感器，这种传感器体积小，可以在不更换电池或充电的情况下舒适地长时间佩戴。该计划将指导开发长期氧疗(LTOT)慢性阻塞性肺病(COPD)患者的家庭监护仪。慢性阻塞性肺疾病合并低氧血症患者长期补充氧气的好处是确凿的。目前，开出氧气的标准方法是对医院或诊所的氧气需求进行静态评估。这种方法背后的假设是，患者将在门诊环境中保持“治疗性”的血红蛋白氧饱和度(SpO2)。最近对24小时脉搏血氧饱和度监测的研究表明，标准处方不能适当地给大多数患者氧合。要解决用于长期连续脉搏血氧仪监测的传感器，必须克服几个技术挑战。为了设计更紧凑的传感器和改进的可穿戴仪器，也许最关键的挑战是开发更节能、更轻的设备。此外，在可穿戴设备能够在家庭中有效使用之前，它们必须变得不显眼，并且不应该阻碍人的移动。标准的手指脉搏血氧仪不适用于许多应用，因为它们会干扰正常的日常工作。 公共卫生相关性：慢性阻塞性肺疾病(COPD)每年在美国造成50多万人住院和100,000多人死亡。人们普遍认为，慢性阻塞性肺疾病慢性呼吸衰竭患者受益于长期氧疗(LTOT)。

DESCRIPTION (provided by applicant): Koronis Biomedical Technology Corporation (KBT) proposes to develop and evaluate a miniature ultralow power pulse oximeter for long-term wearable monitoring. There continues to be a clinical need for an unobtrusive pulse oximeter sensor that is small and can be worn comfortably for extended periods of time without battery change or recharge. This program will direct development efforts towards a home based monitor for chronic obstructive pulmonary disease (COPD) patients on long-term oxygen therapy (LTOT). The benefits of long-term oxygen supplementation in COPD patients with hypoxemia are well established. Currently, the standard approach to prescribing oxygen uses a static assessment of oxygen requirements in a hospital or clinic setting. The assumption behind this approach is that patients will maintain"therapeutic" hemoglobin oxygen saturation (SpO2) in the outpatient setting. Recent studies with 24 hour pulse oximetry monitoring have demonstrated that the standard prescription does not properly oxygenate most patients. Several technical challenges must be overcome to address a sensor for long-term continuous pulse oximetry monitoring. In order to design more compact sensors and improved wearable instrumentation, perhaps the most critical challenges are to develop more power efficient and low weight devices. Additionally, before wearable devices can be used effectively in the home, they must become unobtrusive and should not hinder a person's mobility. Standard finger pulse oximeters are not practical for many applications because they can interfere with normal daily tasks. PUBLIC HEALTH RELEVANCE: Chronic obstructive pulmonary disease (COPD) causes more than 500,000 hospitalizations and more than 100,000 deaths in the United States each year. There is a general agreement that patients with COPD who are developing chronic respiratory failure benefit from long-term oxygen therapy (LTOT).