Bone cements for delivery of osteoinductive growth factors

描述（由申请人提供）：骨水泥广泛用于颌面外科手术、颅骨缺损修复和牙科填充。磷酸钙骨水泥可用于许多类型的骨修复，因为它们符合缺损区域，原位硬化，并且可以被吸收并被新骨取代。当骨水泥是可注射的时，它们也可用于微创手术和填充狭窄的腔和具有有限可及性的缺损。然而，尽管磷酸钙骨水泥具有生物相容性和等温凝固性，但它们仅具有骨传导性，不具有骨诱导性。用生长因子增加材料的生物活性的尝试受到生长因子从材料中快速扩散的限制。因此，对于能够在愈合部位保留和释放骨诱导因子的骨水泥存在显著未满足的临床需求。为此，Affinergy开发了对骨诱导生长因子具有高亲和力的肽。在这个应用中，我们建议使用我们的生长因子结合肽来捕获自体生长因子，并将其与可注射的骨水泥一起递送。除了口腔和颌面外科手术外，最终产品还可以进行改良，用于椎体成形术、治疗有骨折风险的骨质疏松症和微创修复新鲜骨折。 公共卫生相关性：骨水泥在各种手术中支持骨生长，但它们缺乏诱导骨生长的能力。生长因子可以促进骨形成，但由于缺乏最佳载体而受到限制。在这个应用中，我们建议测试一种新的骨水泥作为生长因子的载体。

DESCRIPTION (provided by applicant): Bone cements are widely used in maxillofacial surgery, repair of cranial defects, and dental fillings. Calcium phosphate bone cements are useful in many types of bone repair because they conform to the defect area, harden in situ, and can be resorbed and replaced by new bone. When the cements are injectable, they can also be used for minimally invasive surgery and filling narrow cavities and defects with limited accessibility. However, although calcium phosphate cements are biocompatible and set isothermally, they are only osteoconductive and do not possess osteoinductive properties. Attempts to augment the bioactivity of the material with growth factors have been limited by rapid diffusion of the growth factor away from the material. Therefore, there is a significant unmet clinical need for a bone cement that can retain and release osteoinductive factors at the site of healing. To that end, Affinergy has developed peptides with high affinities for osteoinductive growth factors. In this application, we propose to use our growth factor-binding peptides to capture autologous growth factors and deliver them with an injectable bone cement. In addition to oral and maxillofacial surgery, the final product could be modified for use in vertebroplasty, treatment of osteoporotic bones at risk of fracture, and minimally invasive repair of fresh fractures. PUBLIC HEALTH RELEVANCE: Bone cements support the growth of bone in a variety of procedures, but they lack the ability to induce bone growth. Growth factors can enhance bone formation but are limited by the lack of optimal carriers. In this application, we propose to test a novel bone cement as a carrier for growth factors.