Genetic and Environmental Influences on Personality, Drinking Motives, and Alcoho

遗传和环境对性格、饮酒动机和酒精的影响

• 批准号: 8136470
• 负责人: Andrew Kelley Littlefield
• 金额: $ 3.05万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-09 至 2012-07-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8136470
• 关键词: Accounting; Address; Adolescence; Adult; Age; Alcohol abuse; Alcohols; Behavior; Biological; Biology; Birth; Data; Data Set; Data Sources; Development; Diagnostic; Dimensions; Disease susceptibility; Employee Strikes; Environment; Environmental Exposure; Environmental Risk Factor; Etiology; Exhibits; Exposure to; Female; Female Adolescents; Genes; Genetic; Genetic Risk; Genotype; Goals; Health behavior; Heavy Drinking; Impulsivity; Individual; Individual Differences; Intervention; Interview; Life; Life Style; Link; Longevity; Marriage; Measures; Missouri; Neurotic Disorders; Outcome; Pattern; Personality; Prevalence; Prospective Studies; Questionnaires; Research; Research Personnel; Research Project Grants; Research Training; Role; Sampling; Statistical Methods; Structure; Telephone Interviews; Twin Multiple Birth; Twin Studies; Variant; abstracting; alcohol involvement; alcohol use disorder; cohort; college; drinking; emerging adulthood; follow-up; high risk; improved; prevent; prospective; sex; therapy design; university student; young adult

Project Summary/Abstract Long-Term Objectives: The primary goal of this proposal is to use a lifespan perspective to examine how genetic and environmental factors influence, and interact to influence, problematic alcohol involvement, personality, and drinking motives. Ultimately, the goal of this project is to provide further information on how genes and environment contribute to alcohol involvement, personality, and motives, and to what extent genes and environment explain the relations among these constructs. Specific Aims: The primary aims of this proposal are to prospectively examine measured gene-environment correlations and interactions that contribute to personality constructs as well as drinking motives related to problematic alcohol involvement, and to further determine the extent to which measured gene-environment correlations and interactions contributing to personality and drinking motives account for the relation of these factors with problematic alcohol involvement. These analyses will be conducted in two, multiwave datasets that include genotypic data. Significance: The results from this project could provide information towards improved approaches for identifying, treating, and preventing alcohol use disorders and could clarify how gene-environment correlations and interactions influence alcohol relevant personality, motives, and behaviors.

长期目标：本研究的主要目标是从生命周期的角度来研究遗传和环境因素如何影响和相互影响问题性饮酒、个性和饮酒动机。最终，该项目的目标是提供基因和环境如何影响酒精参与、个性和动机的进一步信息，以及基因和环境在多大程度上解释了这些构式之间的关系。