Neural Mechanisms of Feature Integration

特征整合的神经机制

• 批准号: 8103869
• 负责人: JOHN H REYNOLDS
• 金额: $ 45.5万
• 依托单位: SALK INSTITUTE FOR BIOLOGICAL STUDIES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8103869
• 关键词: Area; Attention; Binding; Color; Color Visions; Data; Dependence; Disease; Exhibits; Functional Magnetic Resonance Imaging; Human; Image; Impairment; Individual; Knowledge; Left; Macaca; Measures; Mediating; Methods; Modeling; Monkeys; Neurobiology; Neurons; Noise; Pathology; Perception; Performance; Photic Stimulation; Play; Problem Solving; Property; Prosopagnosia; Psychophysiology; Resolution; Role; Signal Transduction; Stimulus; Syndrome; Testing; Thinking; Time; Vision; Visual; Visual Agnosias; Visual system structure; area V1; color processing; detector; extrastriate visual cortex; insight; luminance; meetings; neglect; neural model; neuromechanism; object perception; receptive field; relating to nervous system; research study; spatiotemporal; statistics; theories; tool

DESCRIPTION (provided by applicant): A central observation that has driven modern thinking about vision is that the visual system decomposes stimuli into their constituent features, represented by neurons with different feature selectivities. How the signals carried by these feature selective neurons are integrated into coherent object representations is unknown and stands as one of the central unsolved questions in neurobiology. Insight into the mechanisms that solve this problem can be gained by carefully analyzing the temporal properties of perceptual integration at the psychophysical and neuronal levels. We will pursue this strategy, focusing on a simple and well-defined case of feature integration: the conjoining of two of the most basic and well studied features in vision: color and orientation. The central objective of the current proposal is to understand how the visual system conjoins these features. This objective will be met in the following specific aims. Aim 1. Compare the temporal resolution of the visual system for color, orientation and conjunctions of these two features, at the perceptual level and in BOLD in humans, and at the neuronal level in monkeys. Aim 2. Characterize the temporal dynamics of tuning for color and orientation, their dependence on luminance contrast, and quantify any changes in these properties under naturalistic visual stimulation. Aim 3. Test whether spatial attention plays a role in the integration of color and orientation. Relevance: Our current lack of knowledge about the mechanisms of feature integration represents a significant gap in our understanding of the pathology of disorders in which the perception of objects is impaired, such as simultagnosia, prosopagnosia, integrative visual agnosia, Balint's syndrome, and object- centered impairments associated with neglect. Filling this gap will provide understanding that will help in the interpretation and treatment of these and related disorders. The proposed experiments will close this gap by (1) characterizing the temporal resolution of the neural mechanisms that mediate feature integration, (2) developing and testing mathematically rigorous models of the neural computations that mediate a simple and well defined form of feature integration, and (3) determining whether or not attention plays a role in the formation of feature conjunctions.

描述（由申请人提供）：驱动关于视觉的现代思维的中心观察是视觉系统将刺激分解成其组成特征，由具有不同特征选择性的神经元表示。这些特征选择性神经元携带的信号如何整合到连贯的对象表征中是未知的，并且是神经生物学中未解决的核心问题之一。深入了解解决这个问题的机制，可以通过仔细分析的时间特性的知觉整合在心理物理和神经元水平。我们将遵循这一策略，专注于一个简单而定义明确的特征整合案例：将视觉中两个最基本且研究得最好的特征：颜色和方向结合起来。当前提案的中心目标是了解视觉系统如何结合这些功能。这一目标将通过以下具体目标实现。目标1。比较视觉系统的时间分辨率的颜色，方向和这两个功能的连接，在感知水平和BOLD在人类，并在神经元水平的猴子。目标二。描述颜色和方向调节的时间动态及其对亮度对比度的依赖性，并量化自然视觉刺激下这些属性的任何变化。目标3。测试空间注意力是否在颜色和方向的整合中发挥作用。相关性：我们目前缺乏关于特征整合机制的知识，这代表了我们对物体感知受损的疾病的病理学理解的显著差距，所述疾病例如同时失认症、面孔失认症、整合性视觉失认症、巴林特综合征和与忽视相关的以物体为中心的损伤。填补这一空白将提供理解，这将有助于解释和治疗这些和相关的疾病。拟议的实验将通过以下方式缩小这一差距：（1）表征介导特征整合的神经机制的时间分辨率;（2）开发和测试介导简单且定义明确的特征整合形式的神经计算的数学严格模型;（3）确定注意力是否在特征连接的形成中发挥作用。

项目成果

Correction of refractive errors in rhesus macaques (Macaca mulatta) involved in visual research.

矫正参与视觉研究的恒河猴（Macaca mulatta）的屈光不正。

• 发表时间: 2014
• 期刊: Comparative medicine
• 影响因子: 0.8
• 作者: Mitchell,JudeF;Boisvert,ChantalJ;Reuter,JonD;Reynolds,JohnH;Leblanc,Mathias
• 通讯作者: Leblanc,Mathias

The fine structure of shape tuning in area V4.

• DOI: 10.1016/j.neuron.2013.04.016
• 发表时间: 2013-06-19
• 期刊: Neuron
• 影响因子: 16.2
• 作者: Nandy AS;Sharpee TO;Reynolds JH;Mitchell JF
• 通讯作者: Mitchell JF

Attention influences single unit and local field potential response latencies in visual cortical area V4.

• DOI: 10.1523/jneurosci.0489-12.2012
• 发表时间: 2012-11-07
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Sundberg KA;Mitchell JF;Gawne TJ;Reynolds JH
• 通讯作者: Reynolds JH

Contrast dependence of smooth pursuit eye movements following a saccade to superimposed targets.

• DOI: 10.1371/journal.pone.0037888
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Fallah M;Reynolds JH
• 通讯作者: Reynolds JH

Attention-dependent reductions in burstiness and action-potential height in macaque area V4.

• DOI: 10.1038/nn.3463
• 发表时间: 2013-08
• 期刊: NATURE NEUROSCIENCE
• 影响因子: 25
• 作者: Anderson, Emily B.;Mitchell, Jude F.;Reynolds, John H.
• 通讯作者: Reynolds, John H.