THYMIC NURSE CELL ENVIRONMENT IN PATHOGENESIS OF SYSTEMIC LUPUS ERYTHEMATOSUS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 系统性红斑狼疮发病过程中的TNC微环境胸腺护理细胞(TnCs)在限制MHC和清除凋亡胸腺细胞中起着重要作用。随着系统性红斑狼疮(SLE)疾病的发生和发展，跨国公司严重枯竭。这项研究的主要目的是确定狼疮小鼠胸腺中TNCs的替代是否会减少或消除疾病症状。在这些研究中，发现胸腺哺育细胞表达细胞角蛋白5和8(K5和K8)以及转录因子63(Trp-63)。色氨酸蛋白-63的表达是上皮祖细胞的特征。这表明，跨国公司可能具有重新填充狼疮易感小鼠胸腺特有的无上皮区的潜力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The TNC Microenvironment in the Development of Systemic Lupus Erythematosus. Thymic Nurse Cells (TNCs) have a major role in MHC restriction and the removal of apoptotic thymocytes. TNCs are severely depleted with disease onset and progression in systemic lupus erythematosus (SLE). The major goal of this study is to determine if the replacement of TNCs in the thymus of lupus mice will reduce or eliminate disease symptoms. In these studies thymic nurse cells were found to express the cytokeratins five and eight (K5 and K8) as well as the transcription factor 63 (Trp-63). The expression of Trp-63 is a characteristic of epithelial cell progenitors. This suggests that TNCs may have the potential to repopulate epithelial-free zones characteristic of the thymi of lupus-prone mice.