BIOMEDICAL PROTEOMICS FACILITY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 当地和外部研究界已经确定了UCC对蛋白质组设施服务的需求，以支持基础、翻译和临床研究工作。目前，由于缺乏资金和技术支持，这项服务的提供是有限的。UCC的生物医学蛋白质组学设施(BPF)将为研究人员提供分析和鉴定蛋白质的能力，以解决由于缺乏蛋白质组学技术支持而无法研究的基本和翻译研究问题。BPF提供的科学支持将有助于将蛋白质组学纳入基础研究和翻译研究项目，并向授权机构提交新的研究建议。 将实现以下具体目标： 具体目标1：为UCC和波多黎各其他大学内的主要研究人员完成研究项目提供科学和技术支持。 具体目标2：吸引新科学家对蛋白质组学技术感兴趣，并让他们有兴趣利用BPF现有的技术建立合作关系。 具体目标3：与波多黎各学术界和工业界的科学家建立合作关系。 具体目标#4：提供蛋白质组学方法方面的教育和培训。 该设施的目标是将敏感和定量技术应用于相关的生物医学和基础科学问题。到目前为止，BPF在为几名研究人员提供2D凝胶和质谱学初步数据方面发挥了重要作用。最终，BPF将促进学术界和制药业之间建立伙伴关系，使UCC成为蛋白质分析的先锋，并为招募新科学家和在岛内外建立合作做出贡献。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. A need for a proteomic facility service at UCC has been identified by the local and external research community to support basic and translational and clinical research efforts. Currently, this service is provided on a limited basis due to the lack of funding and technical support. The Biomedical Proteomics Facility (BPF) at the UCC will provide researchers with the ability to analyze and identify proteins to address basic and translational research questions that could not be previously studied due to the lack of support in proteomics techniques. The scientific support provided by BPF will facilitate the integration of proteomics into basic and translational research projects and submission of new research proposals to granting agencies. The following SPECIFIC AIMS will be carried out: Specific Aim #1: Provide scientific and technical support to principal investigators within UCC and other universities in Puerto Rico for the accomplishment of research projects. Specific Aim #2: Attract new scientist to the technique of proteomics and interest them in establishing collaborations exploiting the technologies available at BPF. Specific Aim #3: Establish collaboration with scientists in the academia and industry of Puerto Rico. Specific Aim #4: Provide education and training in proteomic methods. The goal of this facility is the application of sensitive and quantitative technologies to relevant biomedical and basic scientific questions. So far the BPF has played an essential role in supplying 2D gels and mass spectrometry preliminary data for several researchers. Ultimately, the BPF will facilitate the establishment of partnerships between the academia and pharmaceutical industry, situating UCC at the vanguard in protein analysis and contributing to the recruitment of new scientist and the establishment of collaborations in and outside of the island.