R&D CMV RELATED HEARING LOSS AND FEASIBILITY OF CMV SCREENING

这份合同的目的是1)解决先天性巨细胞病毒的存在与长期听力学/耳科结果之间的关系，以及2)解决巨细胞病毒筛查在检测新生儿永久性听力障碍方面的临床有效性和实用性，以及预测在婴儿期或生命早期起病的听力障碍。其目标是将出生时的巨细胞病毒状态与永久性和/或进行性感音神经性听力损失的存在联系起来；获得与巨细胞病毒相关的听力损失的发生率、时间进程和听力结果的信息；并确定如果与已经用于新生儿听力筛查的生理指标相结合，巨细胞病毒筛查可以在多大程度上改善对现有或进行性听力损失的检测和预测。

The purpose of this contract is to 1) address the relationship between the presence of congenital CMV and long-term audiologic/otologic outcome, and 2) address the clinical validity and utility of CMV screening in the detection of permanent hearing impairment in the newborn, as well as the prediction of hearing impairment with onset during infancy or in the early years of life. The goals are to correlate CMV status at birth with the presence of permanent and/or progressive sensorineural hearing loss; to acquire information on the incidence, time course and audiologic outcomes of CMV related hearing loss; and to determine the extent to which CMV screening can improve detection and predictions of either existing or progressive hearing loss if combined with physiological metrics already in use for newborn hearing screening.