International Congenital CMV Conference and CMV Workshop

摘要 人巨细胞病毒(CMV)是侵袭性巨细胞病毒病免疫功能受损的重要原因 这是全球先天感染的主要原因之一。侵袭性巨细胞病毒病与免疫性疾病 妥协会导致严重的发病率和死亡率。先天性巨细胞病毒感染是主要的非遗传性感染 美国和世界各地的儿童听力损失。据估计，有3,000到6.000名儿童 每年在美国出生的婴儿都会因先天性巨细胞病毒感染而出现长期的神经发育后遗症。 2019 CMV大会(CMV2019)是第7届双年一度的先天性CMV大会和第17届 国际巨细胞病毒研讨会。这次综合会议汇聚了从事以下各个方面的研究人员 CMV疾病、临床医生、公共卫生政策专家以及家长和倡导者，主要目标是减少 CMV感染带来的疾病负担。将选择的主题包括那些处于CMV前沿的主题 研究和该计划计划传播新的发现，这些发现可以翻译为减少或缓解 先天性巨细胞病毒感染对免疫功能低下个体和婴儿的影响 感染。主题包括(1)巨细胞病毒病在不同临床环境下的分子机制，(2) CMV母婴传播的发病机制，(3)病毒与宿主的相互作用(4)最新知识 病毒遗传多样性及其在传播和疾病中的作用，以及(5)有效的干预和预防 减轻巨细胞病毒感染带来的疾病负担的策略。除了独一无二的研究集合 在主题方面，这次会议为新演讲者、早期调查人员和受训者提供了一个平台。我们会 为受训人员或新调查人员指定一定比例的特邀讲演和会议主席。另外，至少 一半的受邀演讲者和会议主席将是女性。除了口头演示外，还将发布海报 在整个会议期间展示，两个海报会议将在当天结束时延长 演讲者和与会者互动和交流思想的时间段。通过带来最好的CMV 研究界共同努力，本次会议的总体目标是推动该领域向创新方向发展 将研究成果转化为有助于减轻CMV对公共健康影响的研究和新战略 在所有患者群体中都存在疾病。

ABSTRACT Human cytomegalovirus (CMV) is an important cause of invasive CMV disease in immune compromised individuals and a leading cause of congenital infection globally. Invasive CMV disease in patients with immune compromise results in significant morbidity and mortality. Congenital CMV infection is the leading non-hereditary hearing loss in children both in the U.S. and worldwide. It is estimated that between 3,000 and 6.000 children born annually in the U.S. experience long-term neurodevelopmental sequelae from congenital CMV infection. The 2019 CMV Conference (CMV2019) is the combined 7th biannual Congenital CMV Conference and the 17th International CMV Workshop. This integrated meeting brings together researchers working on all aspects of CMV disease, clinicians, public health policy experts and parents and advocates with a primary goal of reducing the disease burden from CMV infections. The topics that will be selected include those at the forefront of CMV research and the program is planned to disseminate new findings that can be translated to reduce or mitigate the consequences of CMV infections in immune compromised individuals and infants with congenital CMV infection. Topics will include (1) molecular mechanisms of CMV disease in various clinical settings, (2) pathogenesis of mother-to-child transmission of CMV, (3) virus-host interactions (4) cutting-edge knowledge on virus genetic diversity and its role in transmission and disease, and (5) effective intervention and prevention strategies to reduce the disease burden from CMV infection. In addition to the unique collection of research topics, this meeting provides a platform for new speakers, early stage investigators, and trainees. We will designate a proportion of invited presentations and session chairs for trainees or new investigators. Also, at least half of invited speakers and session chairs will be women. In addition to oral presentations, posters will be displayed throughout the conference and the two poster sessions will be held at the end of the day with extended periods of time for the presenters and attendees to interact and exchange ideas. By bringing the best of the CMV research community together, the overall goal of this conference is to advance the field towards innovative research and novel strategies for translating research findings to help alleviate the public health impact of CMV disease in all patient populations.