Large Scale Antibody and T Cell Epitope Discovery Program

大规模抗体和 T 细胞表位发现计划

• 批准号: 8316054
• 负责人: DORISA HARRIS
• 金额: $ 10.69万
• 依托单位: TECHNICAL UNIVERSITY OF DENMARK
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2010-01-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8316054
• 关键词: Aminopeptidase; Antibodies; Antigen Presentation Pathway; Arenavirus; B-Lymphocytes; Bacillus anthracis; Binding; Biology; Bioterrorism; Categories; Computing Methodologies; DNA; Data; Dengue; Emerging Communicable Diseases; Epitopes; Francisella tularensis; Gene Mutation; Genomics; Hantaan virus; Human Genome; Influenza; Lassa Fever; Measurement; Methods; Multi-Drug Resistance; National Institute of Allergy and Infectious Disease; Patients; Peptides; Process; Proteins; Screening procedure; Site; Smallpox; T cell response; T-Lymphocyte Epitopes; Tuberculosis; Vaccinated; Vaccines; Vaccinia; Vaccinium; Variant; West Nile virus; Yellow Fever; Yersinia pestis; high throughput screening; improved; interest; novel; pathogen; programs; tool

The Large Scale Antibody and T Cell Epitope Discovery Program will support large scale discovery of novel B and T cell epitopes that utilize recent technological advances. In addition, the program will develop new or improved high throughput screening methods for epitope discovery, with a strong interest in antibody epitope screening methods. This program emphasizes epitope discovery for category A-C bioterrorism agents and emerging/re-emerging infectious diseases.

大规模抗体和T细胞表位发现项目将支持利用最新技术进步大规模发现新的B细胞和T细胞表位。此外，该项目将开发新的或改进的高通量筛选方法，用于发现表位，对抗体表位筛选方法有浓厚的兴趣。该计划强调发现A-C类生物恐怖主义制剂和新出现/再出现的传染病的表位。