In vitro and In Vivo screening of chemopreventive agents

化学预防剂的体外和体内筛选

• 批准号: 8339908
• 负责人: CLINTON GRUBBS
• 金额: $ 40万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-30 至 2012-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8339908
• 关键词: Agreement; Animal Model; Animals; Biological Models; Cancer Control; Cell Culture Techniques; Chemopreventive Agent; Division of Cancer Prevention; In Vitro; Malignant Neoplasms; Modeling; Monitor; Mus; Normal tissue morphology; Organ Culture Techniques; Physical Carcinogens; Preventive; Screening procedure; Work; base; cancer prevention; chemical carcinogen; design; in vivo; insight; man; mutant mouse model; tumor; tumor progression

This Master Agreement proposal is designed to establish and identify the most proficent chemopreventive agent and conditions that will inhibit, reverse or delay cancer. The work under this master agreement proposal is carried out in coordination with the NCI, in the Division of Cancer Prevention (DCP), using state of the art , mechanism-based models, such that insight may be gained about cancer prevention and control in man. The proposal will provide screening and identification of potential cancer preventive agents in mechanism-based in vitro and in vivo.

本主协议提案旨在建立和确定最熟练的化学预防剂和条件，将抑制，逆转或延缓癌症。本总协议提案下的工作是在NCI癌症预防司（DCP）的协调下进行的，使用最先进的、基于机制的模型，这样就可以获得关于人类癌症预防和控制的见解。该方案将在体外和体内提供基于机制的潜在癌症预防剂的筛选和鉴定。