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HHSN261201200020I/HHSN26100006 Title: Preclinical In Vitro And In Vivo Screening Assays For Cancer Preventative Reagent Development, Task Order Title: Evaluation on the Prevention by Actoplus/Met (Pi

HHSN261201200020I/HHSN26100006 Title: Preclinical In Vitro And In Vivo Screening Assays For Cancer Preventative Reagent Development, Task Order Title: Evaluation on the Prevention by Actoplus/Met (Pi
HHSN261201200020I/HHSN26100006 标题：癌症预防试剂开发的临床前体外和体内筛选测定，任务顺序标题：Actoplus/Met 预防的评估 (Pi
批准号：
8945320
负责人：
CLINTON GRUBBS
金额：
$48.91万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-08-26 至 2016-08-25
来源：
https://reporter.nih.gov/project-details/8945320
关键词：
AnimalsBiological AssayBiological MarkersBreast Cancer ModelChemopreventive AgentContractorDataDevelopmentDietDoseEvaluationExperimental DesignsExperimental ModelsFatty acid glycerol estersHistologicIn VitroInsulin ResistanceLesionMalignant NeoplasmsMammary NeoplasmsMammary glandMetabolicMethylnitrosoureaModelingMolecular TargetMouse Mammary Tumor VirusMouse StrainsObesityPharmacodynamicsPreventionProtocols documentationReagentRouteSignal PathwayTestingTransgenic Miceanimal age groupcarcinogenesisdesignin vivomalignant breast neoplasmmeetingspre-clinicalpreclinical efficacypreventscreeningtumor

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英文摘要
This task order is to evaluate preclinical efficacy of ActoPlus/Met in preventing breast cancer in the methylnitrosourea (ER+) mammary cancer model (using a high-fat diet to mimic obesity/insulin resistance), and in the MMTV/Neu (ER-) mammary gland carcinogenesis model (using a high fat diet to mimic obesity).
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