HHSN261201200020I/HHSN26100006 Title: Preclinical In Vitro And In Vivo Screening Assays For Cancer Preventative Reagent Development, Task Order Title: Evaluation on the Prevention by Actoplus/Met (Pi

HHSN261201200020I/HHSN26100006 标题：癌症预防试剂开发的临床前体外和体内筛选测定，任务顺序标题：Actoplus/Met 预防的评估 (Pi

• 批准号: 8945320
• 负责人: CLINTON GRUBBS
• 金额: $ 48.91万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-26 至 2016-08-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8945320
• 关键词: Animals; Biological Assay; Biological Markers; Breast Cancer Model; Chemopreventive Agent; Contractor; Data; Development; Diet; Dose; Evaluation; Experimental Designs; Experimental Models; Fatty acid glycerol esters; Histologic; In Vitro; Insulin Resistance; Lesion; Malignant Neoplasms; Mammary Neoplasms; Mammary gland; Metabolic; Methylnitrosourea; Modeling; Molecular Target; Mouse Mammary Tumor Virus; Mouse Strains; Obesity; Pharmacodynamics; Prevention; Protocols documentation; Reagent; Route; Signal Pathway; Testing; Transgenic Mice; animal age group; carcinogenesis; design; in vivo; malignant breast neoplasm; meetings; pre-clinical; preclinical efficacy; prevent; screening; tumor

This task order is to evaluate preclinical efficacy of ActoPlus/Met in preventing breast cancer in the methylnitrosourea (ER+) mammary cancer model (using a high-fat diet to mimic obesity/insulin resistance), and in the MMTV/Neu (ER-) mammary gland carcinogenesis model (using a high fat diet to mimic obesity).

本任务订单旨在评价ActoPlus/Met在甲基亚硝基脲（ER+）乳腺癌模型（使用高脂饮食模拟肥胖/胰岛素抵抗）和MMTV/Neu（ER-）乳腺癌发生模型（使用高脂饮食模拟肥胖）中预防乳腺癌的临床前疗效。