Brain Metabolites in Type 2 Diabetes and Major Depression Using MRS

描述（由申请人提供）：本资助申请是为Olu Ajilore， MD， PhD获得K23职业发展奖。申请人的目标是发展成为临床神经科学的独立研究者，能够使用尖端的磁共振光谱（MRS）和相关的神经成像方法来检查情绪障碍的神经生物学基础。全面的职业发展计划有三个主要组成部分；1)申请人感兴趣领域的结构化课程作业和研讨会；2)利用内部和外部顾问的指导，获得与临床研究相关的神经影像学、统计学和设计问题的专业知识；3)将作为培训工具的特定项目。主办机构加州大学洛杉矶分校在神经影像学、情绪障碍研究和认知神经科学方面拥有强大的资源，可以帮助申请人完成申请中概述的科学和职业目标。外部顾问是经过精心挑选的，以补充加州大学洛杉矶分校现有的优势和资源。选择这个特定的项目是为了训练Ajilore博士的技术，旨在帮助他追求他的研究兴趣，利用磁共振波谱探测与2型糖尿病和重度抑郁症相关的神经化学扰动。2型糖尿病和重度抑郁症是相互危险因素的疾病，可能具有相似的病理生理机制，如激素失调、免疫功能障碍和脑血管改变。为了进一步了解这些共同的机制，本研究试图在双侧背外侧白质和皮质下核区域的体素中特异性测量谷氨酸，谷氨酸是一种重要的兴奋性神经递质，这两个区域在晚年抑郁症的回路中都很重要。该研究还试图将这些生化变化与2型糖尿病和重度抑郁症患者的认知功能联系起来。有了K23奖，联合项目将提供一个全面的培训计划，以帮助实现候选人在学术精神病学的职业目标。公共卫生相关性：这是一份K23职业发展奖的资助申请，旨在帮助候选人过渡到成为一名独立的研究者，研究与糖尿病和抑郁症相关的大脑结构和化学。糖尿病抑郁症是一个主要的健康问题，不仅影响糖尿病的进展，而且影响糖尿病的后果。这个项目旨在进一步了解这两种疾病之间的关系。

DESCRIPTION (provided by applicant): This grant application is for a K23 Career Development Award for Olu Ajilore, MD, PhD. The objective of the applicant is to develop into an independent investigator in clinical neuroscience with the ability to use cutting edge MR Spectroscopy (MRS) and related neuroimaging approaches to examine the neurobiological basis of mood disorders. The comprehensive career development plan has three primary components; 1) structured course work and seminars in the applicant's area of interest; 2) mentorship utilizing both in house and external consultants to gain expertise in neuroimaging, statistics and design issues related to clinical research and 3) a specific project that will serve as a vehicle for training. Resources at the host institution, the University of California, Los Angeles, are strong in neuroimaging, mood disorders research and cognitive neuroscience and are available to the applicant to accomplish the scientific and career goals outlined in the application. External consultants were chosen carefully to complement the strengths and resources available at UCLA. The specific project was chosen to train Dr. Ajilore in techniques designed to help him pursue his research interests probing the neurochemical perturbations associated with type 2 diabetes and major depression using magnetic resonance spectroscopy. Type 2 diabetes and major depression are disorders that are mutual risk factors and may share similar pathophysiological mechanisms, such as hormonal dysregulation, immunological dysfunction, and cerebrovascular changes. To further understand these shared mechanisms, the proposed study seeks to specifically measure glutamate, an important excitatory neurotransmitter, in voxels placed bilaterally in dorsolateral white matter and the subcortical nuclei regions, both areas important in the circuitry of late-life depression. The study also seeks to correlate these biochemical changes with cognitive function in patients with type 2 diabetes and major depression. With a K23 award, the combined program will provide a comprehensive training schedule to help achieve the candidate's career goals in academic psychiatry. PUBLIC HEALTH RELEVANCE: This is a grant application for a K23 Career Development Award to assist the candidate's transition to becoming an independent investigator studying the brain structure and chemistry associated with diabetes and depression. Depression in diabetes is a major health issue affecting not only the progression but the consequence of diabetes. This project is designed to further understand the relationship between these two illnesses.