Impact of fetal growth restriction on skeletal muscle development, mitochondrial biogenesis and the effect of exercise.

胎儿生长受限对骨骼肌发育、线粒体生物发生和运动效果的影响。

• 批准号: nhmrc : 520662
• 负责人: Dr Rhianna Laker
• 金额: $ 3.88万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/impact-fetal-growth-effect-exercise/115797
• 关键词: Impact; fetal; growth; restriction; skeletal

Being born small is associated with the development of adult diseases. Mitochondria generate energy within cells and impaired function is implicated in disease development. This project aims to define the impact of fetal growth restriction on skeletal muscle development and mitochondrial function in early life and the responsiveness to lifestyle interventions such as improved nutrition and exercise. The outcomes could provide the rationale for clinical and subsequent intervention trials.

出生时身材矮小与成人疾病的发展有关。线粒体在细胞内产生能量，功能受损与疾病发展有关。该项目旨在确定胎儿生长限制对早期骨骼肌发育和线粒体功能的影响，以及对生活方式干预（如改善营养和锻炼）的反应性。这些结果可以为临床和随后的干预试验提供依据。