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Cell Biology of Signaling across Membranes

跨膜信号传导的细胞生物学

基本信息

批准号：
7826050
负责人：
CHRISTOPHER S VON BARTHELD
金额：
$ 214.23万
依托单位：
UNIVERSITY OF NEVADA RENO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-15 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7826050
关键词：
Cell Biology Signaling across Membranes

项目摘要

DESCRIPTION (provided by applicant): Signaling across cell membranes is fundamentally important for normal cellular function and for understanding many diseases. Signal transduction and molecular trafficking are intertwined in ways that make it impossible to truly understand mechanisms of either in isolation. We propose to create a Center of Biomedical Research Excellence (COBRE) at the University of Nevada, Reno (UNR) in the area of cell biology of signaling across membranes. This COBRE will make significant progress in the emerging fusion of the fields of membrane trafficking and signal transduction by examining how molecular signaling is achieved across membranes, both between cells and between subcellular compartments. Five junior faculty with outstanding research accomplishments will use diverse and uniquely advantageous model systems where critical aspects of signaling and transport functions can be examined by molecular, genetic and structural approaches. The proposed research topics will utilize interdisciplinary approaches in the field of signal transduction and molecular trafficking, including growth factor signaling, regulation of gene expression, nuclear and cytoplasmic transport, secretion, endocytosis, apoptosis, and axon guidance. The proposed COBRE is a comprehensive effort that will integrate high-quality biomedical research and expertise in different departments and colleges at UNR under one theme and program. This will bridge the traditional physical and administrative division between the Colleges of Science and Medicine on the upper and lower campus at UNR, and foster interactions that lead to synergism and enhanced biomedical research capacity. The COBRE will provide an efficient mentoring program for junior faculty that will expand already existing training programs at UNR, and support the research of selected young faculty by teaming with clinical mentors and consultants to establish disease focus. The COBRE will provide enhanced infrastructure and technical support for Nevada's new generation of biomedical researchers with truly outstanding credentials and promise for major achievements in biomedical research.

描述（由申请人提供）：跨细胞膜的信号传导对于正常细胞功能和理解许多疾病至关重要。信号转导和分子运输相互交织在一起，使我们不可能真正了解孤立的机制。我们建议在内华达州的里诺大学（UNR）建立一个生物医学研究卓越中心（COBRE），研究跨膜信号传导的细胞生物学。该COBRE将通过研究分子信号如何在细胞之间和亚细胞区室之间跨膜实现，在膜运输和信号转导领域的新兴融合方面取得重大进展。五个具有杰出研究成就的初级教师将使用多样化和独特优势的模型系统，其中信号和运输功能的关键方面可以通过分子，遗传和结构方法进行检查。拟议的研究课题将利用信号转导和分子运输领域的跨学科方法，包括生长因子信号传导，基因表达调控，细胞核和细胞质运输，分泌，内吞作用，凋亡和轴突导向。拟议的COBRE是一项全面的努力，将在一个主题和计划下整合UNR不同部门和学院的高质量生物医学研究和专业知识。这将在UNR上下校区的科学和医学学院之间建立传统的物理和行政分工，并促进互动，从而产生协同作用，提高生物医学研究能力。COBRE将为初级教师提供有效的指导计划，扩大UNR现有的培训计划，并通过与临床导师和顾问合作来支持选定的年轻教师的研究，以建立疾病焦点。COBRE将为内华达州的新一代生物医学研究人员提供增强的基础设施和技术支持，这些研究人员具有真正优秀的资质，并有望在生物医学研究方面取得重大成就。