REU Site: Molecular Biology and Genetics of Cell Signaling

REU 网站：细胞信号传导的分子生物学和遗传学

• 批准号: 1950247
• 负责人: Jun Liu
• 金额: $ 36.59万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1950247&HistoricalAwards=false
• 关键词: REU; Site; Molecular; Biology; Genetics

This REU Site award to Cornell University, located in Ithaca, NY, will support the training of 10 students for 10 weeks during the summers of 2020- 2022. It is anticipated that a total of 30 students, primarily from schools with limited research opportunities or are from an under-represented group, will be trained in the program. Students will learn how research is conducted, and many will present the results of their work at scientific conferences. Assessment of the program will be done through the online SALG URSSA tool. Students will be tracked after the program in order to determine their career paths.The goal of this program is to provide a formative research experience for talented undergraduate students, especially those from underrepresented and disadvantaged groups, that will motivate them to pursue a career in research, help them to be competitive for admission to research intensive graduate programs, and increase their success in these programs. The research focus is in the area of molecular signaling, a process that is fundamental to almost every cellular event. Training faculty are selected from various departments across the campus based on their research interests and their commitment to mentoring undergraduate research. In addition to conducting research in one of the participating labs, weekly REU group meetings with the program directors and various workshops provide students with a broad view of the signaling field in the general area of molecular sciences, opportunities to improve their communication skills, information about graduate school and careers in science, and awareness of responsible conduct of research. Students are also required to take pre- and post-program surveys for program assessment purposes. Students entering their sophomore, junior, or senior years, and majoring in the life sciences are encouraged to apply. Preference will be given to students with strong interest in gaining research experience in preparation for graduate study. Details on the application process, participating mentors and other information about the program are available by visiting https://mbg.cornell.edu/undergraduate/summer-research-experience/, or by contacting the PI (Dr. Kelly Liu at [e-mail]) or the co-PI (Dr. Tim Huffaker at [e-mail]). This award is supported by the Department of Defense ASSURE program thru a partnership with the NSF REU program.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

纽约州伊萨卡市的康奈尔大学的REU网站奖将在2020年至2022年的夏季对10个学生的培训10周，预计总共有30名学生，主要来自研究机会有限或来自代表性不足的小组的学校，将在该计划中接受培训。学生将学习如何进行研究，许多人会在科学会议上介绍他们的工作结果。该程序的评估将通过在线Salg Urssa工具进行。该计划的目的是为学生提供一项成立的研究经验，为才华横溢的本科生，尤其是那些人数不足和处于弱势群体的团体提供一项形成性的研究经验，这将在计划之后进行跟踪。该计划的目的是为他们从事研究职业，帮助他们在研究强度的研究生计划中获得竞争力，并在这些计划中取得成功。研究重点是分子信号传导领域，这是几乎每个细胞事件基础的过程。培训学院是根据他们的研究兴趣以及他们对指导本科研究的承诺从校园各个部门中选出的。除了在一个参与的实验室中进行研究外，与计划主管和各种研讨会的每周REU小组会议还为学生提供了一份分子科学领域的信号传导领域的视野，提高其沟通能力，有关研究生院的信息和科学领域的信息以及对负责任的研究的认识。还要求学生进行计划评估目的的程序前和后图调查。鼓励进入大二，大三或大四的学生，并在生命科学领域进行主修。偏爱对获得研究生学习的研究经验有浓厚兴趣的学生。有关申请过程，参与导师和其他有关该计划的信息的详细信息，可以访问https://mbg.cornell.edu/undergraduate/summer-research-experience/，或通过与PI联系（kelly liu liu a in [e-mail]）或Co-pi（Tim huff at the the the the the the tch4@co）。该奖项由与NSF REU计划的合作伙伴关系得到国防部Assure计划的支持。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的审查标准来评估的。

项目成果

Exo1-protected DNA nicks direct crossover formation in meiosis

Exo1 保护的 DNA 切口在减数分裂中直接交叉形成

• DOI: 10.1101/2021.08.29.458102
• 发表时间: 2021
• 期刊: bioRxiv
• 作者: Gioia M, Payero L

A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain.

• DOI: 10.1021/acschembio.3c00092
• 发表时间: 2023-05-19
• 期刊: ACS CHEMICAL BIOLOGY
• 影响因子: 4
• 作者: Anmangandla, Ananya;Jana, Sadhan;Peng, Kewen;Wallace, Shamar D.;Bagde, Saket R.;Drown, Bryon S.;Xu, Jiashu;Hergenrother, Paul J.;Fromme, J. Christopher;Lin, Hening
• 通讯作者: Lin, Hening

SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans.

• DOI: 10.1371/journal.pbio.3002272
• 发表时间: 2023-08
• 期刊: PLoS biology
• 影响因子: 9.8