Cardiovascular Regenerative Medicine

心血管再生医学

基本信息

  • 批准号:
    8151819
  • 负责人:
  • 金额:
    $ 228.51万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-09-07 至 2016-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Recent data, generated as the result of a decade long effort by the Program PI to develop endothelial progenitor cell based therapeutics, provides evidence for the safety and efficacy of autologous progenitor cells for treatment of myocardial and limb ischemia. Specifically two recent human clinical trials have both yielded evidence that autologous human CD34+ cells improve outcome in patients with chronic, refractory ischemia: patients with intractable angina had significant reductions in chest pain and improved exercise tolerance, while patients with critical limb ischemia had reduced amputation rates. While we acknowledge that the final proof of progenitor cell based therapies in phase III studies is forthcoming, it is our belief that the available evidence for bioactivity and potential therapeutic utility of cell based therapy is substantial enough to justify efforts to augment their efficacy by exploiting our knowledge about their biology and further exploring mechanisms that may enhance their safety and therapeutic utility. The overarching goal of this PPG is to advance the therapeutic use of endothelial progenitor cells for the treatment of cardiovascular diseases. This objective will be achieved in the Program by four individual Projects that investigate certain mechanisms of progenitor cell fate, function and dysfunction, and explore novel, nanomaterial based methods to enhance their therapeutic application and by taking advantage of strategically designed Cores that will support each Project. Project 1: Enhancing Progenitor Cell Function using Bioactive Peptide Amphiphiles (Douglas W. Losordo, M.D. and Samuel Stupp Ph.D., Co-I) Project 2: Role of PAI-1 in Cardiovascular Repair and Fibrosis (Douglas E. Vaughan, M.D., PI) Project 3: Characterization of mitochondrial defects in EPCs in diabetes and aging (Hossein Ardehali, M.D., Ph.D., PI) Project 4: Epigenetic modulation of Endothelial Progenitor Cells for Cardiomyogenesis (Raj Kishore, Ph.D., PI) Core A: Small Animal Surgery and Histology (Tsutomu Kume, Ph.D., PI) Core B: Advanced Molecular Imaging (Tom Meade, Ph.D., PI) Core C: FACS Analysis and Cell Sorting (Harris Perlman, Ph.D., PI) Core D; Administrative Core (Douglas Losordo, M.D., PI) PROJECT 1: Peptide Amphiphiles to Augment Progenitor Cell Therapies (Losordo, Douglas W.)
描述(由申请人提供):

项目成果

期刊论文数量(0)
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DOUGLAS W LOSORDO其他文献

DOUGLAS W LOSORDO的其他文献

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{{ truncateString('DOUGLAS W LOSORDO', 18)}}的其他基金

Novel approaches to ischemic tissue repair
缺血组织修复的新方法
  • 批准号:
    7802049
  • 财政年份:
    2009
  • 资助金额:
    $ 228.51万
  • 项目类别:
Novel approaches to ischemic tissue repair
缺血组织修复的新方法
  • 批准号:
    7635926
  • 财政年份:
    2009
  • 资助金额:
    $ 228.51万
  • 项目类别:
Autologous CD34+ Cell Therapy for Therapeutic Angiogenesis in Advanced PAD
自体 CD34 细胞疗法用于治疗晚期 PAD 的血管生成
  • 批准号:
    7033522
  • 财政年份:
    2006
  • 资助金额:
    $ 228.51万
  • 项目类别:
Autologous CD34+ Cell Therapy for Therapeutic Angiogenesis in Advanced PAD
自体 CD34 细胞疗法用于治疗晚期 PAD 的血管生成
  • 批准号:
    7484974
  • 财政年份:
    2006
  • 资助金额:
    $ 228.51万
  • 项目类别:
Autologous CD34+ Cell Therapy for Therapeutic Angiogenesis in Advanced PAD
自体 CD34 细胞疗法用于治疗晚期 PAD 的血管生成
  • 批准号:
    7171598
  • 财政年份:
    2006
  • 资助金额:
    $ 228.51万
  • 项目类别:
Role of Progenitor Cells in Cardiovascular Medicine
祖细胞在心血管医学中的作用
  • 批准号:
    7171558
  • 财政年份:
    2006
  • 资助金额:
    $ 228.51万
  • 项目类别:
Autologous CD34+ Cell Therapy for Therapeutic Angiogenesis in Advanced PAD
自体 CD34 细胞疗法用于治疗晚期 PAD 的血管生成
  • 批准号:
    7576833
  • 财政年份:
    2006
  • 资助金额:
    $ 228.51万
  • 项目类别:
Role of Progenitor Cells in Cardiovascular Medicine
祖细胞在心血管医学中的作用
  • 批准号:
    7035583
  • 财政年份:
    2006
  • 资助金额:
    $ 228.51万
  • 项目类别:
Role of Progenitor Cells in Cardiovascular Medicine
祖细胞在心血管医学中的作用
  • 批准号:
    7624685
  • 财政年份:
    2006
  • 资助金额:
    $ 228.51万
  • 项目类别:
Role of Progenitor Cells in Cardiovascular Medicine
祖细胞在心血管医学中的作用
  • 批准号:
    7780032
  • 财政年份:
    2006
  • 资助金额:
    $ 228.51万
  • 项目类别:

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BHF Imperial Cardiovascular Regenerative Medicine Centre
BHF帝国心血管再生医学中心
  • 批准号:
    MR/L012618/1
  • 财政年份:
    2013
  • 资助金额:
    $ 228.51万
  • 项目类别:
    Research Grant
Cardiovascular Regenerative Medicine
心血管再生医学
  • 批准号:
    8661256
  • 财政年份:
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  • 项目类别:
Cardiovascular Regenerative Medicine
心血管再生医学
  • 批准号:
    8663728
  • 财政年份:
    2011
  • 资助金额:
    $ 228.51万
  • 项目类别:
Cardiovascular Regenerative Medicine
心血管再生医学
  • 批准号:
    8464219
  • 财政年份:
    2011
  • 资助金额:
    $ 228.51万
  • 项目类别:
Cardiovascular Regenerative Medicine
心血管再生医学
  • 批准号:
    8329605
  • 财政年份:
    2011
  • 资助金额:
    $ 228.51万
  • 项目类别:
Preclinical study of cardiovascular regenerative medicine using asialoerythropoietin
去唾液酸红细胞生成素心血管再生医学的临床前研究
  • 批准号:
    21590887
  • 财政年份:
    2009
  • 资助金额:
    $ 228.51万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
HEMATOPOIETIC STEM CELLS IN CARDIOVASCULAR REGENERATIVE MEDICINE
造血干细胞在心血管再生医学中的应用
  • 批准号:
    7959858
  • 财政年份:
    2009
  • 资助金额:
    $ 228.51万
  • 项目类别:
HEMATOPOIETIC STEM CELLS IN CARDIOVASCULAR REGENERATIVE MEDICINE
造血干细胞在心血管再生医学中的应用
  • 批准号:
    7720834
  • 财政年份:
    2008
  • 资助金额:
    $ 228.51万
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HEMATOPOIETIC STEM CELLS IN CARDIOVASCULAR REGENERATIVE MEDICINE
造血干细胞在心血管再生医学中的应用
  • 批准号:
    7609860
  • 财政年份:
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    $ 228.51万
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造血干细胞在心血管再生医学中的应用
  • 批准号:
    7381237
  • 财政年份:
    2006
  • 资助金额:
    $ 228.51万
  • 项目类别:
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