EFFECTS BRANCHED CHAIN AMINO ACIDS & CAMOSINE PRECURSORS ON MUSCLE DAMAGE

影响支链氨基酸

基本信息

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A majority of the population believes in the benefits of nutritional supplements and takes them regularly. Understanding how different components of supplements interact and the mechanisms of their effects are vital for rational use and recommendations. The branched chain amino acids (BCAA) include leucine, isoleucine and valine and are unique in their effects on skeletal muscle and frequently used to reduce delayed onset muscle soreness and muscle fatigue after exercise. The objective of this work will be to determine whether BCAA and histidine (HIS) or B-alanine (B-ALA), which are precursors for camosine (CAR) synthesis, interact to enhance exercise performance. Carnosine is a dipetide composed of B-ALA and HIS and abundant in muscle and nervous tissue. We hypothesize that the addition of HIS or B-ALA to the BCAA regimen increases CAR levels, which in turn enhances the effectiveness of BCAA because of the CAR's antioxidant and buffering properties. A four-week supplementation period will be used to determine whether complementary effects exist between BCAA and HIS or B-ALA, leading to improved endurance (longer time to fatigue) and attenuation of muscle injury after prolonged low intensity exercise. This would support the concept that exercise performance may be enhanced by a combination of AA supplements. The mechanisms to be examined include the role of oxidative stress and the effect of the supplements on factors related to muscle synthesis and repair. This is of significance for athletes who want to enhance exercise performance and tolerance. Furthermore, the data will lay the groundwork for future studies in the older population for whom exercise tolerance and maintenance of body protein mass are essential to longevity and well-being.
这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者(PI)可能从另一个NIH来源获得了主要资金, 因此可以在其他CRISP条目中表示。所列机构为 研究中心,而研究中心不一定是研究者所在的机构。 大多数人相信营养补充剂的好处,并定期服用。 了解补充剂的不同成分如何相互作用及其作用机制对于合理使用和推荐至关重要。 支链氨基酸(BCAA)包括亮氨酸、异亮氨酸和缬氨酸,并且在它们对骨骼肌的作用方面是独特的,并且经常用于减少运动后的延迟性肌肉酸痛和肌肉疲劳。 这项工作的目的将是确定是否支链氨基酸和组氨酸(HIS)或B-丙氨酸(B-ALA),这是前体camosine(CAR)的合成,相互作用,以提高运动性能。 肌肽是由β-丙氨酸和组氨酸组成的二肽,在肌肉和神经组织中含量丰富。 我们假设在BCAA方案中加入HIS或B-ALA会增加CAR水平,这反过来又会增强BCAA的有效性,因为CAR具有抗氧化和缓冲特性。 为期四周的补充期将用于确定BCAA和HIS或B-ALA之间是否存在互补效应,从而提高耐力(更长的疲劳时间)和减轻长时间低强度运动后的肌肉损伤。 这将支持运动表现可以通过AA补充剂的组合来增强的概念。 要检查的机制包括氧化应激的作用和补充剂对肌肉合成和修复相关因素的影响。 这对于想要提高运动成绩和耐力的运动员具有重要意义。 此外,这些数据将为未来对老年人的研究奠定基础,对老年人来说,运动耐力和维持身体蛋白质质量对于长寿和健康至关重要。

项目成果

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NAOMI K FUKAGAWA其他文献

NAOMI K FUKAGAWA的其他文献

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{{ truncateString('NAOMI K FUKAGAWA', 18)}}的其他基金

Tlp2/COT Regulation of ERK1/2 and NF-kB in Response to Particulates
Tlp2/COT 对 ERK1/2 和 NF-kB 响应颗粒物的调节
  • 批准号:
    8013037
  • 财政年份:
    2010
  • 资助金额:
    $ 0.17万
  • 项目类别:
Tlp2/COT Regulation of ERK1/2 and NF-kB in Response to Particulates
Tlp2/COT 对 ERK1/2 和 NF-kB 响应颗粒物的调节
  • 批准号:
    7777140
  • 财政年份:
    2010
  • 资助金额:
    $ 0.17万
  • 项目类别:
Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and Sex
空气污染物对心血管影响的机制:年龄和性别的影响
  • 批准号:
    7808215
  • 财政年份:
    2009
  • 资助金额:
    $ 0.17万
  • 项目类别:
Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and Sex
空气污染物对心血管影响的机制:年龄和性别的影响
  • 批准号:
    7941803
  • 财政年份:
    2009
  • 资助金额:
    $ 0.17万
  • 项目类别:
AGE-RELATED CHANGES IN GLUTATHIONE METABOLISM
谷胱甘肽代谢与年龄相关的变化
  • 批准号:
    7605792
  • 财政年份:
    2007
  • 资助金额:
    $ 0.17万
  • 项目类别:
AGE-RELATED CHANGES IN GLUTATHIONE METABOLISM
谷胱甘肽代谢与年龄相关的变化
  • 批准号:
    7378574
  • 财政年份:
    2006
  • 资助金额:
    $ 0.17万
  • 项目类别:
AGE-RELATED CHANGES IN GLUTATHIONE METABOLISM
谷胱甘肽代谢与年龄相关的变化
  • 批准号:
    7206952
  • 财政年份:
    2005
  • 资助金额:
    $ 0.17万
  • 项目类别:
GENETIC ALTERATIONS IN HUMAN MUSCLE
人类肌肉的基因改变
  • 批准号:
    7206937
  • 财政年份:
    2005
  • 资助金额:
    $ 0.17万
  • 项目类别:
Genetic Alterations in Human Muscle
人类肌肉的基因改变
  • 批准号:
    7041550
  • 财政年份:
    2004
  • 资助金额:
    $ 0.17万
  • 项目类别:
Stable Isotope Probes for Assessment of Gastric Emptying Times
用于评估胃排空时间的稳定同位素探针
  • 批准号:
    7041542
  • 财政年份:
    2004
  • 资助金额:
    $ 0.17万
  • 项目类别:

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