EVALUATION OF DISORDERS OF FATTY GROWTH

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 通过间接量热法评估患有脂肪疾病的个体；通过组织学和电子显微镜评估患有脂肪疾病的个体的肌肉和脂肪异常；确定患有脂肪疾病的个体和匹配对照之间的脂肪基因表达差异；确定脂肪疾病患者和匹配对照之间的脂肪特异性 FFA 差异； 确定患有脂肪疾病的个体的血液和脂肪标记物； 确定患有脂肪疾病的家族是否具有单核苷酸多态性，这可能有助于深入了解在这些疾病的病因学中重要的基因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Evaluate individuals with fat disorders by indirect calorimetry; evaluate individuals with fat disorders for muscle and fat abnormalities by histology and electron microscopy; determine gene expression differences in fat between individuals with fat disorders and matched controls; determine fat-specific FFA differences between individuals with fat disorders and matched controls; determine blood and fat markers for individuals with fat disorders; determine if families with fat disorders have single nucleotide polymorphisms that may provide insight into genes important in the etiology of these disorders.