EVALUATION OF DISORDERS OF FATTY GROWTH

脂肪生长障碍的评估

• 批准号: 7950955
• 负责人: KAREN Louise HERBST
• 金额: $ 1.19万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950955
• 关键词: Blood; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Disease; Electron Microscopy; Etiology; Evaluation; Family; Fatty acid glycerol esters; Funding; Gene Expression; Genes; Grant; Growth; Histology; Indirect Calorimetry; Individual; Institution; Myopathy; Research; Research Personnel; Resources; Single Nucleotide Polymorphism; Source; United States National Institutes of Health; insight

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Evaluate individuals with fat disorders by indirect calorimetry; evaluate individuals with fat disorders for muscle and fat abnormalities by histology and electron microscopy; determine gene expression differences in fat between individuals with fat disorders and matched controls; determine fat-specific FFA differences between individuals with fat disorders and matched controls; determine blood and fat markers for individuals with fat disorders; determine if families with fat disorders have single nucleotide polymorphisms that may provide insight into genes important in the etiology of these disorders.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 通过间接量热法评估患有脂肪疾病的个体;通过组织学和电子显微镜评估患有脂肪疾病的个体的肌肉和脂肪异常;确定患有脂肪疾病的个体和匹配对照之间的脂肪基因表达差异;确定患有脂肪疾病的个体和匹配对照之间的脂肪特异性FFA差异;确定患有脂肪疾病的个体的血液和脂肪标志物;确定肥胖症家族是否具有单核苷酸多态性，这可能有助于深入了解这些疾病的病因学中的重要基因。