SNP HAPLOTYPING TO DETECT DIABETIC NEPHROPATHY RISK

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 申请者先前获得资助(糖尿病和肾病家族调查，FIND)，目的是在使用微卫星标记的家庭和墨西哥裔美国人无关对象中寻找糖尿病肾病的基因或染色体位置，这些特殊遗传标记是为其在墨西哥裔美国人对象中的特殊用途而开发的。这项合作是在过去5年中通过美国国立卫生研究院资助的“肾病和糖尿病家庭调查(FIND)”项目进行的。目前的申请是FIND(行政上的辅助研究)的延续和延伸。在这个项目中，符合FIND先证者和对照定义的其他在FIND中代表性不足的受试者(例如非西班牙裔欧洲裔美国人)将被招募用于使用新的基因技术进行基因组扫描。这项技术依赖于被称为SNPs(单核苷酸多态)的标记。此外，被招募到FIND的墨西哥裔美国人的DNA也将使用这项新技术进行研究。我们预计，使用这些标记的发现将与使用我们早期研究中的其他技术的发现协同。 研究的好处是，这些研究可能确定增加糖尿病肾病风险的染色体区域和/或基因。这些信息最终可能用于诊断测试和/或为新的治疗方法指明方向。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The applicant was previously funded (Family Investigation of Diabetes and Nephropathy, FIND) to find genes or chromosomal loci for diabetic kidney disease in families using microsatellite markers and in Mexican-American unrelated subjects using special genetic markers that were developed for their particular usefulness in Mexican-American subjects. This collaboration took place over the past 5 years through the NIH-funded project "Family Investigation of Nephropathy and Diabetes (FIND)". The current application is a continuation and an extension of FIND (administratively an ancillary study) . In this project, additional subjects who were under-represented in FIND (eg non-Hispanic European-Americans) who meet the proband and control definitions of FIND will be recruited for the performance of a genome scan using a new genetic technique. The technique is dependent upon markers called SNPs (single nucleotide polymorphisms). In addition, the DNA from the Mexican-American subjects recruited into FIND will also be studied using this new technique. We anticipate that the findings using these markers will synergize with the findings using the other techniques from our earlier study. The benefit to study is that these studies may define chromosomal regions and/or genes that increase the risk for diabetic kidney disease. This information may ultimately be used in diagnostic testing and/or in pointing the way toward new treatments.