SNP HAPLOTYPING TO DETECT DIABETIC NEPHROPATHY RISK

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 申请人先前获得资助（糖尿病和肾病的家庭调查，FIND），使用微卫星标记在家庭中寻找糖尿病肾病的基因或染色体位点，并使用在墨西哥裔美国人受试者中特别有用的特殊遗传标记在墨西哥裔美国人受试者中寻找糖尿病肾病的基因或染色体位点。这项合作是在过去5年中通过NIH资助的项目“肾病和糖尿病家庭调查（FIND）”进行的。当前申请是FIND的延续和扩展（行政上是一项辅助研究）。在本项目中，将招募符合FIND先证者和对照定义的FIND中代表性不足的其他受试者（例如非西班牙裔欧美人），使用新的遗传技术进行基因组扫描。该技术依赖于称为SNP（单核苷酸多态性）的标记。此外，还将使用这种新技术研究被招募到FIND的墨西哥裔美国人的DNA。我们预计，使用这些标记物的发现将与我们早期研究中使用其他技术的发现协同作用。 研究的好处是，这些研究可以确定增加糖尿病肾病风险的染色体区域和/或基因。这些信息最终可能用于诊断测试和/或为新的治疗方法指明方向。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The applicant was previously funded (Family Investigation of Diabetes and Nephropathy, FIND) to find genes or chromosomal loci for diabetic kidney disease in families using microsatellite markers and in Mexican-American unrelated subjects using special genetic markers that were developed for their particular usefulness in Mexican-American subjects. This collaboration took place over the past 5 years through the NIH-funded project "Family Investigation of Nephropathy and Diabetes (FIND)". The current application is a continuation and an extension of FIND (administratively an ancillary study) . In this project, additional subjects who were under-represented in FIND (eg non-Hispanic European-Americans) who meet the proband and control definitions of FIND will be recruited for the performance of a genome scan using a new genetic technique. The technique is dependent upon markers called SNPs (single nucleotide polymorphisms). In addition, the DNA from the Mexican-American subjects recruited into FIND will also be studied using this new technique. We anticipate that the findings using these markers will synergize with the findings using the other techniques from our earlier study. The benefit to study is that these studies may define chromosomal regions and/or genes that increase the risk for diabetic kidney disease. This information may ultimately be used in diagnostic testing and/or in pointing the way toward new treatments.