IDENTIFICATION OF DIABETIC NEPHROPATHY RISK GENES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。确定与糖尿病肾病（ND）相关的基因及其与ESRD的连锁关系（如果有的话）。第二个目的是确定肾病基因，可能是相同的或不同的基因DN。具体目标是：组织一个多中心的联盟来招募表型范围内的参与者：非裔美国人（AA）、墨西哥裔美国人（MA）、高加索/欧洲裔美国人（EA）和印第安人（NA）；利用影响相对对（ARP）、不协调相对对（DRP）和混合连锁不平衡（MALD）连锁分析作图扫描基因组中的连锁染色体区域，并利用传递不平衡检验（TDT）评估这些区域中有连锁证据的候选基因；并利用环境数据作为可能影响遗传易感性的风险因素的指导。这是一项临床横断面研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To identify genes responsible for diabetic nephropathy (ND) and their linkage relationships, if any, to ESRD. A secondary aim is to identify nephropathy genes which may be the same or distinct from the genes of DN. Specific aims are to: organize a multi-centered consortium to undertake the recruitment of participants within a phenotypic range African-American (AA), Mexican-American (MA), and Caucasian/European Americans (EA), and Native Americans (NA); use affected relative pair (ARP), discordant relative pair (DRP), and mapping by admixture linkage disequilibrium (MALD) linkage analyses to scan the genome for linked chromosomal regions, and the transmission disequilibrium test (TDT) to evaluate candidate genes in those regions with evidence for linkage; and use environmental data as a guide for possible risk factor effects on genetic susceptibility. This is a clinical research cross sectional study.