ADOLESCENT BARIATRICS ASSESSING HEALTH BENEFITS AND RISKS (TEEN-LABS U01 DK07249

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 为了促进和加速减肥手术的研究，国家糖尿病与消化和肾脏疾病研究所（NIDDK）建立了减肥手术联盟（LABS）的纵向评估。LABS研究项目，按照最初的设想，只关注接受减肥手术的成年受试者。然而，还设立了一个辅助研究机制，以支持其他相关的研究项目。Teen-LABS就是这样一个相关项目。这项观察性Teen-LABS研究的主要目的是收集正在接受减肥手术的青少年的基线特征和术后结局，以评估减肥手术的安全性和有效性。通过镜像LABS数据收集，Teen-LABS研究还将使我们能够估计与延迟手术相比，极端肥胖青年早期手术的相对优点。这种比较将导致更好地了解重要的医学和心理社会肥胖相关的合并症的可塑性。此外，这项研究将提供关键的科学信息，告知临床决策有关减肥手术的适当时机。 青春期严重肥胖与医疗和心理社会障碍有关，在青春期手术治疗可能比成年后更有效。 具体目标1：确定寻求减肥手术的青少年和成人之间的健康是否存在显著差异，从而确定在一生中早期而不是晚期进行减肥手术是否有潜在的年龄相关健康益处。 具体目标2：确定接受减肥手术的青少年和成人的早期（30天）和中期（1-2年）健康风险。 具体目标3：记录减肥手术前和手术后1年和2年极度肥胖的青少年和成人的心理社会状况。心理社会状况将在三个主要领域进行检查：抑郁症状，饮食行为和生活质量。 具体目标4：获取并储存生物标本（血清、血浆、全血和肝组织），用于与本研究目的相关的研究，并供本联盟和辅助研究将来用于研究肥胖症的病理生理学和遗传学以及肥胖症相关问题。 减肥手术是治疗成人极度肥胖的有效方法，最常用于50岁以上的人群。随着越来越多的青少年发展为极度肥胖并寻求减肥手术，我们的长期目标是阐明青少年手术减肥的健康益处和风险。我们的中心假设是，青春期的严重肥胖与医疗和心理社会障碍有关，在青春期手术治疗可能比成年后更有效。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To facilitate and accelerate research in Bariatric Surgery, the National Institute of Diabetes & Digestive, and Kidney Diseases (NIDDK) established the Longitudinal Assessment of Bariatric Surgery consortium (LABS). The LABS research project, as originally conceived, focused only on adult subjects undergoing bariatric surgery. However, an ancillary studies mechanism was also established to support other related research projects. Teen-LABS is one such related project. The primary goal of this observational Teen-LABS study is to collect baseline characteristics and postoperative outcomes of adolescents who are undergoing bariatric surgery in an effort to assess safety and efficacy of bariatric surgery. By mirroring LABS data collection, the Teen-LABS study will also allow us to estimate the relative merits of early surgery compared to delayed surgery for extremely obese youth. This comparison will lead to a better understanding of the plasticity of important medical and psychosocial obesity-related comorbidities. Moreover, this study will provide critical scientific information to inform clinical decision-making regarding appropriate timing of bariatric surgery. Severe obesity in adolescence is associated with medical and psychosocial impairments which may be more effectively treated with surgery during adolescence rather than later in adulthood. Specific Aim 1: To determine whether health significantly differs between adolescents and adults seeking bariatric surgery and thereby determine whether there are potential age-related health benefits in performing bariatric surgery earlier rather than later in the lifetime. Specific Aim 2: To identify early (30 day) and intermediate term (1-2 year) health risks for adolescents and adults undergoing bariatric surgery. Specific Aim 3: To document the psychosocial status of adolescents and adults with extreme obesity before bariatric surgery and 1 and 2 years after surgery. Psychosocial status will be examined in three major domains: depressive symptoms, eating behaviors, and quality of life. Specific Aim 4: To obtain and store biospecimens (serum, plasma, whole blood, and liver tissue) for research related to the aims of this study, and for future use by this consortium and ancillary studies for research into the pathophysiology and genetics of obesity and obesity related issues. Bariatric surgery is effective in treating extreme obesity in adults, and is most commonly used in the 5th decade of life. As more adolescents develop extreme obesity and seek bariatric surgery, our long term goal is to elucidate the health benefits and risks of surgical weight loss for adolescents. Our central hypothesis is that severe obesity in adolescence is associated with medical and psychosocial impairments which may be more effectively treated with surgery during adolescence rather than later in adulthood.