ADOLESCENT BARIATRICS ASSESSING HEALTH BENEFITS AND RISKS (TEEN-LABS U01 DK07249

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 为了促进和加速减肥外科的研究，美国国家糖尿病、消化和肾脏疾病研究所(NIDDK)成立了减肥外科纵向评估联盟(LABS)。按照最初的设想，实验室的研究项目只关注接受减肥手术的成年受试者。然而，还设立了一个辅助研究机制，以支持其他相关的研究项目。青少年实验室就是这样一个相关的项目。这项观察性青少年实验室研究的主要目标是收集正在接受减肥手术的青少年的基线特征和术后结果，以努力评估减肥手术的安全性和有效性。通过反映实验室收集的数据，青少年实验室的研究还将使我们能够评估对于极度肥胖的年轻人来说，早期手术与延迟手术相比的相对优点。这种比较将有助于更好地理解与肥胖相关的重要医学和心理社会并发症的可塑性。此外，这项研究将提供关键的科学信息，为临床决策提供适当的减肥手术时机。 青春期的严重肥胖与医学和心理社会障碍有关，青春期的手术治疗可能比成年后的手术更有效。 具体目标1：确定寻求减肥手术的青少年和成年人之间的健康是否有显着差异，从而确定在一生中较早而不是较晚进行减肥手术是否有潜在的与年龄相关的健康益处。 具体目标2：确定接受减肥手术的青少年和成人的早期(30天)和中期(1-2年)健康风险。 具体目标3：记录青少年和成人极端肥胖患者在减肥手术前以及手术后1年和2年的心理社会状况。心理社会状况将在三个主要领域进行检查：抑郁症状、饮食行为和生活质量。 具体目标4：获取和存储生物标本(血清、血浆、全血和肝组织)，用于与本研究目标相关的研究，并供该联盟和辅助研究将来用于肥胖和肥胖相关问题的病理生理学和遗传学研究。 减肥手术在治疗成人极端肥胖方面是有效的，并且在人生的第五个十年中最常用。随着越来越多的青少年发展为极端肥胖并寻求减肥手术，我们的长期目标是阐明手术减肥对青少年的健康益处和风险。我们的中心假设是，青春期的严重肥胖与医学和心理社会障碍有关，而青春期的手术治疗可能比成年后的手术更有效。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To facilitate and accelerate research in Bariatric Surgery, the National Institute of Diabetes & Digestive, and Kidney Diseases (NIDDK) established the Longitudinal Assessment of Bariatric Surgery consortium (LABS). The LABS research project, as originally conceived, focused only on adult subjects undergoing bariatric surgery. However, an ancillary studies mechanism was also established to support other related research projects. Teen-LABS is one such related project. The primary goal of this observational Teen-LABS study is to collect baseline characteristics and postoperative outcomes of adolescents who are undergoing bariatric surgery in an effort to assess safety and efficacy of bariatric surgery. By mirroring LABS data collection, the Teen-LABS study will also allow us to estimate the relative merits of early surgery compared to delayed surgery for extremely obese youth. This comparison will lead to a better understanding of the plasticity of important medical and psychosocial obesity-related comorbidities. Moreover, this study will provide critical scientific information to inform clinical decision-making regarding appropriate timing of bariatric surgery. Severe obesity in adolescence is associated with medical and psychosocial impairments which may be more effectively treated with surgery during adolescence rather than later in adulthood. Specific Aim 1: To determine whether health significantly differs between adolescents and adults seeking bariatric surgery and thereby determine whether there are potential age-related health benefits in performing bariatric surgery earlier rather than later in the lifetime. Specific Aim 2: To identify early (30 day) and intermediate term (1-2 year) health risks for adolescents and adults undergoing bariatric surgery. Specific Aim 3: To document the psychosocial status of adolescents and adults with extreme obesity before bariatric surgery and 1 and 2 years after surgery. Psychosocial status will be examined in three major domains: depressive symptoms, eating behaviors, and quality of life. Specific Aim 4: To obtain and store biospecimens (serum, plasma, whole blood, and liver tissue) for research related to the aims of this study, and for future use by this consortium and ancillary studies for research into the pathophysiology and genetics of obesity and obesity related issues. Bariatric surgery is effective in treating extreme obesity in adults, and is most commonly used in the 5th decade of life. As more adolescents develop extreme obesity and seek bariatric surgery, our long term goal is to elucidate the health benefits and risks of surgical weight loss for adolescents. Our central hypothesis is that severe obesity in adolescence is associated with medical and psychosocial impairments which may be more effectively treated with surgery during adolescence rather than later in adulthood.