MULTI-CENTER TRIAL TO EVALUATE HOME-BASED ASSESSMENT METHODS FOR ALZHEIMER DISEA

评估阿尔茨海默病家庭评估方法的多中心试验

• 批准号: 8166928
• 负责人: RUTH MULNARD MCCARGAR
• 金额: $ 0.05万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166928
• 关键词: Alzheimer' s Disease; Clinic; Clinical; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Conduct Clinical Trials; Drops; Funding; Grant; Health Resources; Home environment; Impaired cognition; Individual; Institution; Lead; Medical; Methods; Persons; Prevention; Research; Research Personnel; Resources; Risk; Sample Size; Site; Source; Time; Transportation; United States National Institutes of Health; Visit; base; cost; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is an unmet need for effective, efficient and economical methods for conducting clinical trials to prevent Alzheimer s disease. Traditional in-person visits to a clinic are time consuming and costly and may exclude certain individuals from participation, such as those who are older, or are less mobile or who have significant medical illnesses. These may be the very people who are at greatest risk for cognitive decline, as well as those without financial resources for transportation to a study site. Prevention trials also require long observation periods and these same issues of health, resources, and transportation may cause significant drop out. These obstacles increase expense of clinical trials as they require large sample sizes, costly clinical staff and long observation periods. Thus, home-based assessments may lead to more representative recruitment of those most at risk for decline, better retention and reduced study costs.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 对于进行临床试验以防止阿尔茨海默氏病的有效，高效和经济的方法，需要有效，高效和经济的方法。传统的面对诊所的面对面访问时间耗时且昂贵，可能会将某些人排除在参与之外，例如年龄较大的人，流动性较小或患有严重的医疗疾病。这些可能是认知能力下降的风险最大的人，以及没有财务资源来运输到研究地点的人。 预防试验还需要长时间的观察期，而且健康，资源和运输的同样问题可能会导致大量退出。这些障碍增加了临床试验的费用，因为它们需要大量样本量，昂贵的临床人员和长期观察期。因此，基于家庭的评估可能会导致更具代表性的招募人士的招募，而这些人最有可能下降，更好的保留和降低研究成本的人。