RANDOMIZED, DOUBLE-BLIND TRIAL OF CLINDAMYCIN, TRIMETHOPRIM-SULFAMETHOXAZOLE, OR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 金黄色葡萄球菌是一种细菌，可导致皮肤感染和其他严重和致命的感染。社区相关耐甲氧西林金黄色葡萄球菌(CA-MRSA)是一种对多种抗生素耐药的金黄色葡萄球菌感染类型。CA-MRSA感染突然变得非常普遍，而10年前还闻所未闻。CA-MRSA对许多抗生素都有耐药性，所以医生不确定哪种抗生素对皮肤感染最有效，现在皮肤感染主要是由CA-MRSA引起的。 为了了解如何最好地治疗皮肤感染，特别是所谓的简单皮肤和软组织感染？(USSTI)，我们需要做一项临床试验，比较专家认为最好的抗生素。然而，没有证据表明这些抗生素有多好(有效)或安全。 我们将在CA-MRSA常见地区的儿童和成人中进行uSSTI治疗的临床试验，特别是脓肿(脓肿)和/或蜂窝织炎(温和皮肤感染)的治疗。本研究的主要目的是比较克林霉素和甲氧苄啶-磺胺甲恶唑(TMP-SMX)两种抗生素治疗uSSTI的治愈率。治疗将与脓肿治疗的护理标准相结合，即切开和引流(即刺穿脓肿)。有初步信息表明，对于小脓肿的患者，仅切开引流而不使用抗生素可能就足够了。因此，有小脓肿的受试者将随机接受克林霉素、TMP-SMX或安慰剂治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Staphylococcus aureus (Staph) is a germ that can cause skin infections and other serious and deadly infections. Community-Associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are types of Staph infections that are resistant to many antibiotics. CA-MRSA infections are suddenly very common, whereas 10 years ago they were unheard of. CA-MRSA are resistant to many antibiotics so doctors are not sure which antibiotics work best against skin infections, which are now caused mostly by CA-MRSA. To understand how to best treat skin infections, specifically ones called ?uncomplicated skin and soft tissue infections? (uSSTIs), we need to do a clinical trial to compare antibiotics that experts think are best. However, there is no proof about how good (efficacious) or safe these antibiotics are. We will perform a clinical trial of treatment of uSSTIs --specifically treatment of abscesses (boils) and/or cellulitis (bland skin infection)--in both children and adults in areas where CA-MRSA is common. The primary objective of this study is to compare the cure rates of two antibiotics, clindamycin and trimethoprim-sulfamethoxazole (TMP-SMX) for the treatment of uSSTIs. Treatment will be done in conjunction with the standard of care for treatment of abscesses, which is incision and drainage (i.e., lancing a boil). There is preliminary information that incision and drainage alone without antibiotics may be sufficient for patients with small abscesses. Therefore, subjects with small abscesses will be randomized to be treated with either clindamycin, TMP-SMX, or placebo.