COBRE: UNE MED CTR: CORE B: MOUSE GENOME ENGINEERING

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这个COBRE提案的一个目标是建立一个三角形UNMC-Creighton-Boys Town NRH， 在神经感觉发育卓越研究中心。在所有人的承诺下 三个机构对人类的保健，小鼠将是最重要的模式生物的未来 生物医学研究这个话题。因此，鼠标核心的存在和可用性不会 仅通过现场建立相关小鼠使初始COBRE研究者受益 模型，但将作为一个重要的招聘工具，一旦最初的COBRE调查员将轮换 新的调查员会被带上船我们预计，这些征聘人员还将侧重于 老鼠，使用基因操纵的老鼠来推进他们的研究。特别是初级调查员 如果您对鼠标的使用经验有限，则可以从Mouse Core支持服务中受益匪浅。 此外，我们期望本建议的几个项目的表达谱实验 将产生值得产生新的转基因和基因敲除小鼠模型的结果， 为了研究它们在神经感觉发育中的功能，我们对各自的基因进行了研究。因此我们 相信鼠标核心的可用性将大大提高新的竞争力， COBRE提案所支持的校外资金申请。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. One goal of this COBRE proposal is to establish the triangle UNMC-Creighton-Boys Town NRH as a recognized Center of Research Excellence in Neurosensory Development. With the commitment of all three institutions to human health care, the mouse will be the paramount model organism for future biomedical research on this topic. The presence and availability of a Mouse Core will, therefore, not only benefit the initial COBRE Investigators through the on-site establishment of the pertinent mouse models, but will serve as an essential recruiting tool once the initial COBRE Investigators will rotate off and new Investigators will be brought aboard. We anticipate that such recruits will also focus on the mouse, use genetically manipulated mice to advance their research. In particular, junior Investigators with limited experience with mice would greatly benefit from Mouse Core support services. Furthermore, we expect that the expression profiling experiments of several projects of this proposal will yield results that merit the generation of new transgenic and knockout mouse models for the respective genes in order to study their function in neurosensory development. We are therefore convinced that the availability of a Mouse Core will significantly enhance the competitiveness of new applications for extramural funding that are fostered by this COBRE proposal.