Loyola Alcohol Research Center (LARC)

描述(由申请者提供)：本次P30拨款申请的总体目标是：1)通过NIH拨款的生物医学研究核心中心支持新教师的招聘，以增强研究资源；2)建立洛约拉酒精研究中心(LARC)。我们预计，获得这笔P30资助将使我们能够更好地将我们的酒精研究兴趣引导到酒精与伤害的方向，并使我们在未来P30酒精研究中心的资助申请中变得更具竞争力。LARC的研究主题源于伊丽莎白·J·科瓦奇博士和Loyola更广泛的酒精研究计划(ARP)成员正在进行的实验室工作，他们继续进行重叠但独立的研究，旨在确定过度饮酒增加受伤或感染后组织损害并阻碍后续修复过程的机制。在美国，近50%的成人烧伤和创伤患者的伤势严重到需要住院治疗，他们在受伤前饮酒。最近的证据表明，这些受试者中的绝大多数并不依赖饮酒者，而是在急性或狂欢的基础上饮酒。因此，研究一次或多次酗酒后的伤害对患者的影响既具有临床意义，又具有重要意义。与P30机制的目标一致，科瓦奇博士和他的同事计划招聘一名具有共同兴趣的终身教职助理教授，加入这个积极的、多学科的研究和培训小组，专注于酒精和组织损伤。科瓦奇博士和一批精挑细选的教职员工将担任学员的资深导师和同行导师。她和导师将帮助新员工建立自己的独立研究计划，并促进她融入小组项目，这些项目将加速中心的研究计划。加入互动式研究团队将加快新教员的进度，并使他/她能够掌握这一临床相关问题的知识和技能 公共卫生相关性：P30拨款申请的总体目标是支持新教师的招聘，以促进酒精和组织损伤/修复方面的研究。需要住院的成人烧伤和创伤患者中，近一半在受伤前饮酒。来自我们小组和其他人的证据表明，在受伤前饮酒会增加组织损伤，并阻碍随后的修复过程。

DESCRIPTION (provided by applicant): The overall goals of this P30 grant application are to 1) support New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers for NIH grant and 2) establish the Loyola's Alcohol Research Center (LARC). We anticipate that obtaining this P30 grant will enable us to better direct our alcohol research interests in the direction of alcohol and injury and allow us to become more competitive in a future P30 Alcohol Research Center grant application. The theme of the research at LARC stems from ongoing work in the laboratory of Dr. Elizabeth J. Kovacs and members of Loyola's broader Alcohol Research Program (ARP), who continue to work on overlapping but independent studies designed to determine the mechanisms by which binge alcohol exposure increases tissue damage after an injury or infection and impedes the subsequent repair process. In the United States, nearly 50% of the adult burn and trauma patients who sustain injuries severe enough to require hospitalization consumed alcohol prior to their injuries. Recent evidence reveals that the vast majority of these subjects are not dependent drinkers, but rather consume alcohol on an acute or binge basis. Thus, performing studies that examine the effects of single or multiple binge drinking episodes followed by injury is both clinically relevant and significant. Consistent with goals of the P30 mechanism, Dr. Kovacs and colleagues plan to recruit a new tenure-track assistant professor with common interests to join this active, multi-disciplinary research and training group focusing on alcohol and tissue injury. Dr. Kovacs and a select group of faculty will serve as senior and peer mentors for the trainee. She and the mentors will help the new recruit to establish her own independent research program and facilitate her integration into to group projects that will lead toward acceleration of the research initiatives of the Center. Joining an interactive research team will accelerate the progress of the new faculty member and allow him/her knowledge and skills to this clinically relevant problem PUBLIC HEALTH RELEVANCE: The overall goal of this P30 grant application is to support new faculty recruitment to facilitate research in alcohol and tissue injury/repair. Nearly half of the adult burn and trauma patients who require hospitalization consumed alcohol prior to their injuries. Evidence from our group and others reveals that consuming alcohol prior to injury increases tissue damage and impedes the subsequent repair process.