2021 and 2023 Alcohol-Induced End Organ Diseases Gordon Research Conference

2021 年和 2023 年酒精引起的终末器官疾病戈登研究会议

• 批准号: 10574538
• 负责人: ELIZABETH J. KOVACS
• 金额: $ 2.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-20 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10574538
• 关键词: Acceleration; Acute; Address; Alcohol abuse; Alcohol consumption; Alcoholic Liver Diseases; Alcohols; Area; Arrhythmia; Automobile Driving; Breast; Cells; Chronic; Clinical Investigator; Collaborations; Colon; Communities; Development; Diabetes Mellitus; Diagnosis; Discipline; Disease; Drug abuse; Economic Burden; Ensure; Environment; Epidemic; Etiology; Fetal Alcohol Syndrome; Formulation; Fostering; Future; Future Generations; Goals; Health; Height; Hypertension; Immunologics; Individual; Injury; International; Knowledge; Lead; Liver; Longevity; Malignant Neoplasms; Metabolic syndrome; Methodology; Modeling; Molecular; Morbidity - disease rate; Myocardial Ischemia; Obesity; Organ; Osteoporosis; Pancreatitis; Pathway interactions; Pneumonia; Postdoctoral Fellow; Prevention; Research; Research Personnel; Risk; Scientific Advances and Accomplishments; Shapes; Societies; Stroke; Structure; Techniques; Time; Tissues; Underrepresented Minority; Upper respiratory tract; Work; alcohol abuse therapy; alcohol effect; alcohol exposure; alcohol misuse; alcohol research; alcohol use disorder; body system; career; experience; insight; meetings; minority scientist; mortality; next generation; novel strategies; organ injury; organ repair; peer; posters; pre-clinical; prevent; repaired; research and development; student participation; symposium; synergism; therapeutic development; therapeutically effective; tissue injury; unpublished works

Abstract Alcohol misuse is one of the world's leading preventable health risks. Alcohol use and abuse is a causal factor in over 60 different diseases and injuries putting an enormous health and economic burden on societies worldwide. The major share of alcohol-induced morbidity and mortality is attributable to alcohol-induced end organ diseases, including cancer, alcoholic liver disease, pancreatitis, osteoporosis, diabetes mellitus, hypertension, ischemic heart disease, arrhythmias, stroke, pneumonia and fetal alcohol syndrome. Alcohol use disorders are on the rise in all segments of society and they often synergize with other diseases that have reached epidemic proportions including obesity, diabetes, metabolic syndrome, drug abuse and immunological maladies. Despite the significant advances of the field over the last two decades, the underlying disease etiology is poorly understood and there is an urgent need to gain new knowledge of the molecular underpinnings of alcohol-induced end organ diseases to accelerate diagnosis, prevention, and treatment. In this R13 application, we are seeking support for the Gordon Research Conferences (GRC) Alcohol-induced End Organ Diseases 2021 and 2023. This is a relatively new GRC, which was initiated three years ago held extremely successful meetings in 2017 and 2019. The open format of GRC model includes sharing significant unpublished work and provides ample opportunities for in-depth discussions with peers, new colleagues and the future generation of alcohol researchers; this conference model is ideally suited for propelling the field to new heights. The overall goal of the Alcohol-induced End Organ Diseases meetings are to foster open discussion of research developments, establish new scientific collaborations, and propel the next generation of scientific advances. This GRC fills a critical need in the field for a continuing meeting that presents key recent findings on alcohol-induced end organ injury and repair in a unique format that ensures time for in-depth discussions, formulation of new approaches and initiation of new collaborations. This conference will 1) provide a forum that promotes open discussion of cutting edge research at the forefront of alcohol-induced tissue injury, 2) foster the development of the next generation of alcohol and tissue injury investigators, 3) promote interaction between young and senior investigators, 4) facilitate the exchange of ideas that will shape the future directions of the alcohol and tissue injury community and 5) introduce breakthrough techniques that facilitate the understanding of mechanisms driving alcohol-induced tissue injuries. We envision the GRC on “Alcohol induced end organ diseases” will significantly advance current understanding of the underlying mechanisms of end organ injuries and stimulate development of effective therapeutic strategies for the diagnosis, prevention and treatment of alcohol use disorders.

摘要 酒精滥用是世界上主要的可预防健康风险之一。酒精使用和滥用是一个因果因素 60多种不同的疾病和伤害，给社会带来巨大的健康和经济负担， 国际吧酒精引起的发病率和死亡率的大部分是由于酒精引起的疾病。 器官疾病，包括癌症、酒精性肝病、胰腺炎、骨质疏松症、糖尿病， 高血压、缺血性心脏病、心律失常、中风、肺炎和胎儿酒精综合征。酒精使用 疾病在社会各阶层都在增加，它们往往与其他疾病协同作用， 肥胖、糖尿病、代谢综合征、药物滥用和免疫系统疾病等已成为流行病。 疾病尽管该领域在过去二十年中取得了重大进展，但潜在的疾病 病因学知之甚少，迫切需要获得新的分子知识， 酒精诱导的终末器官疾病的基础，以加速诊断，预防和治疗。在 这个R13应用程序，我们正在寻求支持戈登研究会议（GRC）酒精诱导 最终器官疾病2021年和2023年。这是一个比较新的集贸市场，它是三年前发起的， 在2017年和2019年举行了非常成功的会议。GRC模型的开放格式包括共享重要的 未发表的工作，并提供了与同行，新同事和 未来一代的酒精研究人员;这种会议模式非常适合推动该领域， 新的高度酒精诱导的终末器官疾病会议的总体目标是促进开放的 讨论研究进展，建立新的科学合作，并推动下一代的 科学进步。该GRC满足了该领域对持续会议的迫切需求，该会议提出了最近的关键 关于酒精引起的终末器官损伤和修复的研究结果，以独特的形式，确保深入研究的时间 讨论、制定新的办法和开展新的合作。本次会议将（1）提供 一个论坛，促进在酒精诱导组织的前沿研究的公开讨论 损伤，2）促进下一代酒精和组织损伤研究人员的发展，3）促进 青年和高级研究人员之间的互动，4）促进将塑造未来的思想交流 酒精和组织损伤社区的方向和5）引入突破性技术， 对酒精诱导的组织损伤机制的理解。我们设想的GRC是关于“酒精 诱导的终末器官疾病”将大大推进目前对 终末器官损伤，并刺激有效的治疗策略的诊断，预防和发展 和酒精使用障碍的治疗。