5ALPHA-REDUCTASE INHIBITORS FOR REDUCTION OF PROSTATE EPITHELIAL CELL GROWTH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 前列腺癌是最常见的男性癌症。因此，防治这种癌症的预防和/或治疗战略可能会对公众健康产生深远影响。5？还原酶抑制剂非那雄胺(Proscar？)和度他雄胺(Avodart？)通常用于治疗良性前列腺增生症(BPH)，但也可能潜在地减缓前列腺癌的发展和/或进展。5？-还原酶将睾酮转化为更有效的雄激素二氢睾酮，这对推动 大多数前列腺癌的生长。具体目标1将检查非那雄胺和度他雄胺在肿瘤植入之前或之后开始的有效性。锯棕榈提取物也被用来治疗BPH，据报道可以降低5？-还原酶，但其报道的效果有很多不一致之处。尽管锯棕榈的效果令人怀疑，但它是美国人常用的，在植物学销售中排名前五，前列腺癌男性也经常使用。我们认为，不同研究之间的不同结果可能是由于提取物的营养成分不同，据报道，这些提取物的营养成分差异很大。具体目标2，我们将收集常用的商用锯棕榈提取物，并对其营养特性进行表征。然后，我们将确定提取物的营养特性是否与其抑制前列腺癌上皮细胞5？-还原酶和细胞增殖的能力相对应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prostate cancer is the most commonly diagnosed male cancer. Thus, preventative and/or therapeutic strategies to combat this cancer could have a profound impact on public health. The 5¿-reductase inhibitors finasteride (Proscar¿) and dutasteride (Avodart¿) are commonly used to treat benign prostatic hyperplasia (BPH) but may also potentially decrease the development and/or progression of prostate cancer. 5¿-reductase enzymes convert testosterone to the more potent androgen dihydrotestosterone, which is important for driving the growth of most prostate cancers. Specific Aim 1 will examine the effectiveness of finasteride and dutasteride when begun before or after tumor implantation. Saw palmetto extracts have also been used to treat BPH and are reported to decrease 5¿-reductase enzymes, but there has been a lot of inconsistency their reported effectiveness. Despite the saw palmetto's questionable effectiveness, it is commonly used by Americans, ranking in the top 5 of botanical sales and is commonly used by men with prostate cancer. We believe that the variable results between studies may be due to differences in the extracts nutrient profiles, which have been reported to vary widely. Specific Aim 2 we will collect commonly used commercial saw palmetto extracts and characterize their nutrient profiles. We will then determine whether an extract's nutrient profile correspond to its ability to inhibit 5¿-reductase and cell proliferation of prostate cancer epithelial cells.