SEROTONIN, IMPULSIVITY, AND HEALTH-RISK BEHAVIORS

血清素、冲动和健康风险行为

• 批准号: 8168017
• 负责人: SCOTT F STOLTENBERG
• 金额: $ 2.24万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168017
• 关键词: Autonomic nervous system; Behavior; Behavior Disorders; Computer Retrieval of Information on Scientific Projects Database; Decision Making; Development; Funding; Gender; Genes; Genetic; Genetic Variation; Goals; Grant; Health; Impulsivity; Individual Differences; Institution; Life; Measures; Mediating; Mental disorders; Methods; Neurotic Disorders; Neurotransmitters; Personality Traits; Persons; Play; Prevention; Probability; Regulation; Research; Research Personnel; Resources; Risk; Risk Behaviors; Role; Serotonin; Source; System; Testing; Uncertainty; United States National Institutes of Health; base; receptor; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Making decisions in situations where the probabilities of success are either completely unknown (i.e. uncertainty) or known (i.e. risk) is an important part of a person's everyday life and can have significant health consequences. There are individual differences in decision-making that are likely due to a person's biologically based autonomic nervous system reactivity. Genetic variation in components of neurotransmitter systems (e.g. receptors or transporters) is likely to play an important role in autonomic nervous system activation and regulation. Our long-term goal is to facilitate the development of prevention and treatment methods for mental illness and behavioral disorders based on an understanding of the mechanisms that influence the propensity to engage in health-risk behaviors (HRB) via genetic variation in neurotransmitter systems and their subsequent influence on behavior. It is in that context that we are proposing to examine basic mechanisms involved with decision-making. We will test the following hypotheses: a. Measures of autonomic activation are associated with decision-making and with the personality trait Neuroticism. b. Genetic differences on decision-making are mediated by autonomic activation. c. Gender moderates the associations between neurotransmitter genes and decision-making.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在成功概率是完全未知的情况下（即不确定性）或已知（即风险）是一个人日常生活的重要组成部分，并且可能带来重大的健康后果。 决策中存在个体差异，可能是由于一个人基于生物学的自主神经系统的反应性。 神经递质系统（例如受体或转运蛋白）成分的遗传变异可能在自主神经系统的激活和调节中起重要作用。 我们的长期目标是基于对通过神经递质系统中遗传变异及其对行为影响的遗传变异来促进针对精神疾病和行为障碍的预防和治疗方法的发展。 正是在这种情况下，我们建议研究与决策有关的基本机制。 我们将检验以下假设： 一个。 自主激活的度量与决策和人格特质神经质有关。 b。 决策的遗传差异是由自主激活介导的。 c。 性别调节神经递质基因与决策之间的关联。