ACETYLATION DEPENDENT STAT3 SIGNALOSOME IN LIVER CANCER

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 通过从人和大鼠HCC细胞系中鉴定、分离和表征CSC、CSCM和非CSC，获得CSC存在于HCC中的额外证据。具体目标2：确定CSC和非CSC中STAT 3信号体的状态。具体目标3：对于表现出组成性激活的CSC，确定破坏信号体的影响。 具体目标4：确定HCC祖细胞中STAT 3信号体的状态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Acquire additional evidence that CSC are present in HCC by Identifying, isolating and characterizing CSC, CSCM and non-CSC from human and rat HCC cell lines. Specific Aim 2: Determine the status of the STAT3 signalosome in CSC and non-CSC. Specific Aim 3: For CSC showing constitutive activation, determine the effects of disrupting the signalosome. Specific Aim 4: Determine the status of the STAT3 signalosome in progenitors of HCC.