ACETYLATION DEPENDENT STAT3 SIGNALSOME IN LIVER CANCER

肝癌中乙酰化依赖性 STAT3 信号体

• 批准号: 8359718
• 负责人: Y. Eugene Chin
• 金额: $ 5.18万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359718
• 关键词: Acetylation; Cell Line; Centers of Research Excellence; Funding; Grant; Human; Malignant neoplasm of liver; NCI Center for Cancer Research; National Center for Research Resources; Principal Investigator; Rattus; Research; Research Infrastructure; Resources; STAT3 gene; Source; United States National Institutes of Health; cost; progenitor; research and development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Acquire additional evidence that CSC are present in HCC by identifying, isolating and characterizing CSC, CSCM and non-CSC from human and rat HCC cell lines. Specific Aim 2: Determine the status of the STAT3 signalsome in CSC and non-CSC. Specific Aim 3: For CSC showing constitutive activation, determine the effects of disrupting the signalsome. Specific Aim 4: Determine the status of the STAT3 signalsome in progenitors of HCC.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 通过从人和大鼠肝癌细胞系中鉴定、分离和鉴定CSC、CSCM和非CSC，获得肝癌中存在CSC的更多证据。具体目标2：确定STAT3信号体在CSC和非CSC中的状态。具体目标3：对于显示结构性激活的CSC，确定干扰信号体的影响。具体目标4：确定STAT3信号体在肝细胞癌前体细胞中的状态。