THEORY OF NERVE PULSE TRANSFER BASED ON NON-LINEAR DIFFUSION OF K

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标1：求解一个因依赖而改变边界条件的非线性微分方程组 Rd=f(C)，其中c是靠近外膜边界的K+离子浓度，Rd=Duw/dl是微分 膜在v.c.c点处的阻力。电压U和电流I。结果是，我们将得到 发展的时间和空间的不稳定性。积分这个方程就有可能得到这个量 由于一个脉冲而到达轴突的离子K+。实验结果：~3.6x10“12摩尔/厘米~2/脉冲。 时间上的不稳定性(公式16，[11])将给出脉冲增长部分的整个时间。实验结果： 大约0.5毫秒。 具体目标2：更完整地描述神经脉冲传递的过程，同时考虑到 膜电流的钠组分。众所周知，这一组件在 膜电位变化的动力学。 具体目标3：进一步完善该理论。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1: To solve a nonlinear differential equation with the changing boundary condition due to the dependency Rd = f(c), where c is a concentration of K+ ions near the outer membrane boundary, and Rd = dUw/dl is the differential resistance of the membrane at the point of the v.c.c. with voltage U and current I. As the result, we will obtain the development of the non-stability in time and space. Integrating the equation will make it possible to obtain the quantity of ions K+ that arrive at the axon due to one pulse. Experimental results: ~3.6xlO"12 Mole/cm2/pulse. The determination of the non-stability in time (eq.16, [11]) will give the entire time of the growing part of the pulse. Experimental results: approximately 0.5 msec. Specific Aim 2: To describe the process of the nerve pulse transfer in a more complete way taking into account the sodium component of the membrane current. This component, as it is known, plays a very important role in the dynamics of the change in the membrane potential. Specific Aim 3: Further refinement of the theory.