EQUIPMENT GRANT - FT-IR SPECTROMETER

设备赠款 - 傅立叶变换红外光谱仪

• 批准号: 8167546
• 负责人: Christopher Mathew Burba
• 金额: $ 4.45万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167546
• 关键词: Address; Affect; Binding; Bone Regeneration; Cells; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Education; Electrolytes; Equipment; Extracellular Matrix; Faculty; Funding; Grant; Human; Institution; Ions; Iron; Laboratory Research; Marines; Metals; Microbial Biofilms; Native Americans; Pharmaceutical Preparations; Polymers; Reaction; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Route; Science; Secure; Series; Source; Spectrum Analysis; Stretching; Students; Surface; United States National Institutes of Health; Universities; Vitamin D Analog; analytical tool; chelation; fungus; improved; instrument; metal oxide; microbial; microwave electromagnetic radiation; novel; repaired

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. FT-IR spectroscopy is a major analytical tool used to characterize novel materials used in the biomedical sciences. As such, it is among the core instruments that compose research laboratories across the world. This proposal calls for the acquisition of a research-grade FT-IR spectrometer at Northeastern State University to improve the research infrastructure and student education at the NSU (Tahlequah) campus. The FT-IR spectrometer will replace an older infrared spectrometer that was primarily used in faculty research projects. The older infrared spectrometer ceased functioning towards the end of January 2009 and cannot be repaired. Replacement of the broken FT-IR is critical as several research projects currently funded through external agencies depend on FT-IR spectroscopy to address the proposed research objectives. The requested FT-IR spectrometer will be available for faculty to use in their own research projects. A brief list of these projects includes: + Characterize a series of artificial extracellular matrices that enhance bone regeneration in humans. + Investigate the mechanism for conductivity enhancement in stretched polymer electrolytes. + Examine the chelation effects between iron-binding compounds secreted by marine fungi and metal ions. + Characterize the initial steps in microbial biofilm formation by understanding the interactions between microbial cells and metal oxide surfaces. + Characterize reaction products in the microwave-assisted gynthesis of medications. + Development of alternative reaction routes for the synthesis of novel vitamin D analog anticancer compounds. The FT-IR spectrometer will greatly strengthen the research infrastructure of the university, thereby supporting faculty development in research. In addition, the instrument will be vital for producing preliminary data to secure additional funding. A broader impact of acquiring the instrument is its affect on the severe under-representation of Native Americans in the biomedical sciences.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 FT-IR光谱是一种主要的分析工具，用于表征生物医学科学中使用的新材料。因此，它是组成世界各地研究实验室的核心仪器之一。该提案要求在东北州立大学购买研究级FT-IR光谱仪，以改善NSU（Tahlequah）校园的研究基础设施和学生教育。FT-IR光谱仪将取代主要用于教师研究项目的旧红外光谱仪。旧的红外线分光计在2009年1月底停止运作，无法修复。更换损坏的FT-IR至关重要，因为目前通过外部机构资助的几个研究项目依赖于FT-IR光谱来解决拟议的研究目标。所要求的FT-IR光谱仪将可供教师在自己的研究项目中使用。这些项目的简要清单包括： + 描述一系列增强人类骨再生的人工细胞外基质的特征。 + 研究拉伸聚合物电解质电导率增强的机理。 + 研究海洋真菌分泌的铁结合化合物与金属离子的螯合作用。 + 通过了解微生物细胞和金属氧化物表面之间的相互作用，表征微生物生物膜形成的初始步骤。 + 表征微波辅助药物合成中的反应产物。 + 开发用于合成新型维生素D类似物抗癌化合物的替代反应路线。 FT-IR光谱仪将大大加强大学的研究基础设施，从而支持教师的研究发展。此外，该工具对于生成初步数据以确保额外资金至关重要。获得该仪器的更广泛影响是其对美洲原住民在生物医学科学中代表性严重不足的影响。