PROGRAM LEADERS---CANCER PREVENTION

癌症预防和人口科学（CPPS）项目的目标是通过开展创新的多学科癌症预防和人口科学研究来减少癌症的发病率和影响。CPPS项目有来自贝勒多个部门的31名研究成员，包括医学、儿科、外科、泌尿外科、精神病学和神经科学。其中包括5名新成员，他们是由癌症中心协助招募到贝勒大学的；此外，6名贝勒大学尼古丁依赖生物行为方面的研究人员也加入了CPPS。该项目去年从NCI获得了4,561,452美元的支持，总共获得了10,035,029美元的同行评审资金。该项目成员在同行评审期刊上发表了300多篇癌症相关论文，其中29%是项目内合作，12%是项目间合作。我们的项目在概念上分为两个广泛的主题领域：(1)癌症流行病学和遗传学：CPPS研究人员进行研究，检查儿童和成人癌症的病因，并研究基因和基因的贡献

The goal of the Cancer Prevention and Population Sciences (CPPS) Program is to reduce the incidence and impact of cancer by conducting innovative multidisciplinary cancer prevention and population sciences research. The CPPS Program has 31 research members from a multiple Departments at Baylor, including Medicine, Pediatrics, Surgery, Urology, Psychiatry, and Neuroscience. These include 5 new members whose recruitment to Baylor was facilitated by the Cancer Center; in addition, 6 Baylor investigators in the biobehavioral aspects of nicotine dependence have joined CPPS. The program had $4,561,452 support from the NCI last year and overall received $10,035,029 in peer reviewed funding. Members of the program published over 300 cancer related manuscripts in peer-reviewed journals of which 29% were intraprogrammatic collaborations and 12% interprogrammatic. Our program is conceptually organized into two broad thematic areas: (1) Cancer Epidemiology and Genetics: CPPS Investigators conduct studies to examine the etiology of childhood and adulthood cancers, and to study the contribution of gene and gene environment interactions to their etiology; and to identify the clinical and molecular characteristics of syndromes that result in hereditary predisposition to cancers. Other CPPS investigators evaluate the cancer outcomes especially to address health disparities and inequities in access, treatment, and survival. Major accomplishments include analyses of secular trends and risk factors for several digestive and liver cancers, identification of genetic polymorphisms that are associated with risk of childhood and adult tumors as well as for premalignant lesions such as Barrett's esophagus and liver cirrhosis, (2) Biobehavioral Research and Cancer Prevention: This theme is focused on Childhood Obesity and Physical Activity, in which investigators study the determinants of obesity and physical activity in children and adolescents, and evaluate culturally appropriate interventions; Nicotine Dependence in which investigators examine the genetics of addictive behavior, in both animal models and human studies, and to evaluate novel interventions for smoking cessation; and Chemoprevention research to test novel prevention agents in animals and in human trials. Major accomplishments in this theme include the development of interventional programs to improve childhood diet and exercise to combat childhood obesity, the role of genetics in nicotine dependence through study of nicotinic receptors, and the conduct of breast cancer prevention clinical trials.