Admin Core

抽象--管理核心 该计划项目的目标是减少与肝细胞癌相关的死亡率负担 通过更好地了解当代风险因素(例如，表型、生化和遗传标记) 代谢功能障碍)与代谢相关的肝细胞癌的预防策略(如化学预防) (功能障碍)相关性脂肪肝(MAFLD)。为了实现这一目标，我们提出了3个项目，2个共享 资源核心：Biosecimen和Biomarker开发核心、数据和分析核心，以及 管理核心。行政核心将管理该计划，运行财务和运营， 协调小组之间的关系，并支持项目计划。 我们建议建立一个运行良好的行政核心，拥有强大和经验丰富的领导层，这将是 计划项目及其支持的研究和核心项目的成功。哈什姆·塞拉格博士，世界卫生组织主席 休斯顿贝勒医学院的医学系将担任行政核心主任。 贝勒医学院消化和肝科科长Fasiha Kanwal博士将担任 副主任。这两个都是经验丰富的跑步中心和核心。一名计划项目管理员 将为日常财务管理和业务提供必要的支持。执行委员会 一个外部咨询委员会将进行监督。执行委员会将由以下成员组成 主管、副主任、核心主管和项目负责人每月举行会议。外部咨询 委员会将由4名外部专家组成，包括肝癌生物学、流行病学、预防以及 协调中心活动。 管理核心的目标是：(1)建立一个具有强大领导能力的核心来管理计划 项目；(2)使用优化的方法管理该计划的科学、管理和财务职能； 以及(3)支持项目调查员与外部顾问之间的协调和沟通 合作者。行政核心将提供集中的行政和科学领导，以促进 计划项目所有组件之间的协同互动。核心将为以下方面提供平台 每月召开所有项目和核心项目的绩效指标会议，分享进度和结果，并排除故障 有问题。行政核心将对照时间表和里程碑跟踪项目和核心的进展情况 通过可访问的实时电子仪表盘和评估项目、核心和整体的绩效 程序。行政核心还将实施一个基于网络的软件，以跟踪服务的使用和进行 网络研讨会、会议和会议。行政核心执行委员会还将提供 为调查人员提供平台，以影响项目计划的运作。

ABSTRACT—Administrative Core The goal of the Program Project is to reduce the burden of hepatocellular carcinoma (HCC)-related mortality through better understanding of contemporary risk factors (e.g., phenotypic, biochemical and genetic markers of metabolic dysfunction) and preventive strategies (e.g., chemoprevention) of HCC related to metabolic (dysfunction) associated fatty liver disease (MAFLD). To accomplish this goal, we propose 3 Projects, 2 shared resource Cores: Biospecimen and Biomarker Development Core and Data and Analysis Core, and the Administrative Core. The Administrative Core will govern the Program, run the finances and operations, coordinate between groups, and support the Program Project. We propose a well-run Administrative Core with strong and experienced leadership that will be essential to the success of the Program Project and the studies and cores it supports. Dr. Hashem El-Serag, Chair of the Department of Medicine at Baylor College of Medicine, Houston will be the Director of the Administrative Core. Dr. Fasiha Kanwal, Section Chief of Gastroenterology and Hepatology at Baylor College of Medicine will be the Associate Director. Both are highly experienced running Centers and Cores. One Program Project administrator will provide the necessary support for day-to-day financial management and operations. An Executive Committee and an External Advisory Committee will perform oversight. The Executive Committee will be composed of the Director, Associate Director, Core Directors, and Project Leaders who will meet monthly. The External Advisory Committee will comprise of 4 external experts in liver cancer biology, epidemiology, prevention as well as coordinating center activities. The Aims of the Administrative Core are: (1) to build a Core with strong leadership to manage the Program Project; (2) to use optimized methods for managing the Program’s scientific, regulatory, and financial functions; and (3) to support coordination and communication between Program investigators and outside advisors and collaborators. The Administrative Core will provide centralized administrative and scientific leadership to facilitate synergistic interactions among all components of the Program Project. The core will provide a platform for monthly meeting for the PIs of all projects and cores to meet and share progress and results and troubleshoot problems. The Administrative Core will tracking progress of Projects and Cores against timelines and milestones via accessible real-time electronic dashboards and evaluating performance of Projects, Cores, and the overall Program. The Administrative Core will also implement a web-based software to track service use and conduct webinars, meetings, and conferences. The Executive Committee of the Administrative Core will also provide platform for investigators to influence the operations of the Program Project.